Bi2S3-SiO2 NRs/二被氧化硅金属涂层塑炼铋纳米级棒多模态显影液剂可以选择于肠胃道GI三维成像水平

利于浓盐酸钡透明桌面液用作X光显影液剂于结肠成相，致使其人体必备的非化学降解和他些不自然的优势使其在肠胃道打孔及直肠构造监测方便备受较大局限；许多普遍的肠胃道显影液剂都是碘代碳原子，但故有本就X放射线溶解率较低，故此一般 须要大用量使用的方能提升理想化的疗效，这无时无刻会使缺乏行成碘皮肤敏感性反應。

提纯受到二防氧化硅涂覆的塑炼铋微米棒（Bi2S3@SiO2 NRs）身为多模态定影剂适用于直肠内的无性侵犯性及时影像或者真接检测其在直肠内下方的交界期间（Scheme 1）。经二腐蚀硅包裹后，在胃及结肠中，Bi2S3@SiO2 NRs显显现出极为好的水可溶，动物相溶性同时稳固性。顺利通过TEM可能看不出，Bi2S3 NRs宽约10 nm，约长50 nm，稀土元素具体分析谱图表现非常成功配制得见高溶解度的Bi2S3 NRs（Fig. 1），经二硫化硅涂覆后，Bi2S3@SiO2 NRs显示单离心分离性，SiO2壳层料厚约为6 nm（Fig. 2）。

Fig. 1 Characterization of Bi2S3 NRs. (A) HAADF-STEM image and (B) HRTEM image of Bi2S3 NRs prepared by the solvothermal method. (C) Corresponding element mapping for Bi and S of the as-prepared Bi2S3 NRs. (D) EDS of the as-prepared Bi2S3 NRs.

Fig. 2 Characterization of Bi2S3@SiO2 NRs. (A) TEM image and (B) HRTEM image of as-prepared Bi2S3@SiO2 NRs. Inset: HAADF-STEM image of Bi2S3@SiO2 NRs. (C) Corresponding element mapping for Bi, S and Si of Bi2S3@SiO2 NRs. (D) EDS of Bi2S3@SiO2 NRs.

根据CT显像分享发现，发生变化Bi₂S₃@SiO₂ NRs氧浓度提升，其HU值明显的添加，同一渗透压下的HU值比较突出如果超过硫酸钠钡，PAT信息随渗透压延长也呈平滑提升问题（Fig. 3）。

Fig. 3 CT and PAT phantom images of Bi2S3@SiO2 NRs with different concentrations in vitro. (A) Plot of Hounsfield units (HU) values and of Bi2S3@SiO2 NRs and BaSO4 suspension versus the sample concentrations and CT phantom images of Bi2S3@SiO2 NRs and BaSO4 suspension samples with different concentrations. (B) Plot of the photoacoustic signal versus Bi2S3@SiO2 NRs concentrations and PAT phantom images of Bi2S3@SiO2 NRs aqueous solutions with different concentrations.

对Bi2S3@SiO2 NRs的海洋生物相溶性做判断，表明16HBE与Bi2S3@SiO2 NRs共陪养24 h后仍找不到表现出非常显著的的渗透性，还有就是该塑料再生颗粒迈入景色宜人隐杆线虫里面后对其寿命短也找不到非常显著的的后果，这就说明书怎么写Bi2S3@SiO2 NRs含有很好的怪物混溶性（Fig. 4）。

Fig. 4 Biosafety assessment of Bi2S3@SiO2 NRs by the C. Elegans model. (A) Bright field image of the NRs distribution in the GI tract of C. Elegans. Worms feed on NGM plates with Bi2S3@SiO2 NRs (1000 μg mL−1) transferred onto an agar pad after 1 h. (B) The distribution of food containing Bi2S3@SiO2 NRs (red arrows) in the intestine of the worm’s tail. (C) Effects of Bi2S3@SiO2 NRs with different concentrations on body length of C. Elegans. (D–H) Effects of Bi2S3@SiO2 NRs treatments on the accumulation of lipofuscin in age-synchronized worms. Representative fluorescent images of worms fed with 0, 1, 10, 100 and 1000 μg mL−1 Bi2S3@SiO2 NRs, respectively.

Bi2S3@SiO2 NRs以服用的方试进到BALB/c裸鼠人体内，采用CT及PAT对Bi2S3@SiO2 NRs实现时时激光散斑关注，会发现该颗粒经由消化道道悄悄加入结肠较后以排泄物的样式出排身体，该进程中对消化道道的功能键无很大的受损，说明书怎么写Bi2S3@SiO2 NRs对公司无侵扰性断裂（Fig. 5, 6, 7）。

Fig. 5 CT imaging of the GI tract in vivo. In vivo X-ray CT imaging of the GI tractin BALB/c nude mice at different intervals after oral administration of Bi2S3@SiO2 NRs.

Fig. 6 Enlarged images of CT images of the GI tract of mice 30 min post oral administration of Bi2S3@SiO2 NRs.

Fig. 7 PAT imaging of the GI tract in vivo. PAT cross-sectional image of the GI tract of BALB/c nude mice at different intervals after oral administration of Bi2S3@SiO2 NRs: stomach (ST), small intestine (SI) and large intestine