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DSPE-PEG-Cholic acid胆酸修饰脂质体(功能性脂质体)负载DOX·HCl的特性
发布时间:2025-06-20     作者:zyl   分享到:
参考文献:Novel DSPE-PEG-Cholic Acid-Modified Liposomes with Hepatic Targeting Properties Improve the Anti-Tumor Efficacy of Oral Doxorubicin Hydrochloride for Liver Tumor-Bearing MiceDOI: 笔者: Li, Ying; Yang, Dandan; Zhang, Yun; Zhu, Chunyan论文摘要:DSPE-PEG-cholic acid-modified liposomes (functional liposomes) with hepatic targeting via oral administration properties were explored for the loading of DOX·HCl. DSPE-PEG-cholic acid-modified DOX·HCl liposomes (functional DOX·HCl liposomes) were developed as an oral therapy that targets hepatic cancers. Subsequently, the effects of liposome formulations were investigated using in vitro HepG2 cell uptake assays, in vivo intestine distribution and targeting efficacy experiments in orthotopic HepG2 nude mice xenograft tumors and subcutaneous H22 mice xenograft tumors. Functional DOX·HCl liposomes of approximately 100 nm in diameter significantly increased the intracellular uptake of DOX·HCl, revealing strong inhibitory effects on HepG2 cells. Moreover, orally administered functional DOX·HCl liposomes demonstrated stronger antitumor efficacy than DOX·HCl and DOX·HCl liposomes in orthotopic HepG2 xenograft mice, but similar antitumor efficacy to DOX·HCl liposomes in subcutaneous H22 xenograft mice. In further analyses, cardiac and kidney toxicities were significantly reduced after orally administering functional DOX·HCl liposome formulations. The present data indicate that the oral administration of functional DOX·HCl liposomes increases hepatic targeting, provides superior efficacy of suppressing xenograft tumor, and overcomes limited cardiac and kidney toxicity.

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探究了借助服食给药体现了肝靶向药物药物性的DSPE-PEG-胆酸绘制脂质体(模块性脂质体)载荷DOX·HCl的特征参数。的开发了DSPE-PEG-胆酸绘制的DOX·HCl脂质体(模块性DOX·HCl-脂质体)对于靶向药物药物肝癌的服食方式。那么,用身体之外HepG2神经元摄入耐压、体内的肠子分布区和原位HepG2裸鼠异种移栽后癌症和皮内H22小鼠异种移栽后癌症的靶向药物的疗效实验报告分析了脂质制度剂的影响力。直徑约为100 nm的基本功能DOX·HCl脂质体强势增长了DOX·HCI的神经元内摄入,对HepG2神经元屏幕上显示出猛烈的能够抑拍摄用。与此同时,在原位HepG2异种人授物小鼠中,服食功用键性DOX·HCl脂质体比DOX·HCI和DOX·HCl脂质体拥有更强的抗肿癌效应,但在皮下组织H22异种人授物鼠中,其抗肿癌效应与DOX·硝酸脂质体一样。在全面一个脚印的分折中,服食功用键性DOX·HCl脂质构成剂后,肝脏和肾脏毒副作用为显著大幅度降低。到目前为止的数据分析是因为,服食功用键性DOX·HCl脂质体可延长肝靶向治疗性,打造调控异种人授物肿癌的好见效,并缓解有限的的肝脏和肾脏毒副作用。关联推介:DSPE-PEG-FITCDSPE-PEG-FolateDSPE-PEG-IADSPE-PEG-MalDSPE-PEG-NH2DSPE-PEG-NHSDSPE-PEG-OHDSPE-PEG-propargylDSPE-PEG-AlkyneDSPE-PEG-Rhodamine版权局声明函:本系统不同对应科技发展学术期刊文章、辅导大纲甚至网站建设编译整理出来的游戏内容,仅用到对对应有效散文集的介紹、点赞甚至课程辅导或有效探讨。告之侵权案,请练习各位误删。