资料：Novel DSPE-PEG-Cholic Acid-Modified Liposomes with Hepatic Targeting Properties Improve the Anti-Tumor Efficacy of Oral Doxorubicin Hydrochloride for Liver Tumor-Bearing MiceDOI: 做者: Li, Ying; Yang, Dandan; Zhang, Yun; Zhu, Chunyan小结：DSPE-PEG-cholic acid-modified liposomes (functional liposomes) with hepatic targeting via oral administration properties were explored for the loading of DOX·HCl. DSPE-PEG-cholic acid-modified DOX·HCl liposomes (functional DOX·HCl liposomes) were developed as an oral therapy that targets hepatic cancers. Subsequently, the effects of liposome formulations were investigated using in vitro HepG2 cell uptake assays, in vivo intestine distribution and targeting efficacy experiments in orthotopic HepG2 nude mice xenograft tumors and subcutaneous H22 mice xenograft tumors. Functional DOX·HCl liposomes of approximately 100 nm in diameter significantly increased the intracellular uptake of DOX·HCl, revealing strong inhibitory effects on HepG2 cells. Moreover, orally administered functional DOX·HCl liposomes demonstrated stronger antitumor efficacy than DOX·HCl and DOX·HCl liposomes in orthotopic HepG2 xenograft mice, but similar antitumor efficacy to DOX·HCl liposomes in subcutaneous H22 xenograft mice. In further analyses, cardiac and kidney toxicities were significantly reduced after orally administering functional DOX·HCl liposome formulations. The present data indicate that the oral administration of functional DOX·HCl liposomes increases hepatic targeting, provides superior efficacy of suppressing xenograft tumor, and overcomes limited cardiac and kidney toxicity.

摸索了经过口服药药给药还具有肝靶向治疗药物性的DSPE-PEG-胆酸装饰脂质体（基本能力上脂质体）装载DOX·HCl的性能特点。制作了DSPE-PEG-胆酸装饰的DOX·HCl脂质体（基本能力上DOX·HCl-脂质体）成为靶向治疗药物肝癌的口服药药中医疗法。继而，用到身体外HepG2血癌神经元摄入量试验装置、胃中肠腔匀称和原位HepG2裸鼠异种人授肿癌和皮内H22小鼠异种人授肿癌的靶向治疗较果的研究的研究了脂质机制剂的影响力。内径约为100 nm的职能性DOX·HCl脂质体可观增添了DOX·HCI的血癌神经元内摄入量，对HepG2血癌神经元显现出浓烈的仰设计制功用。凡此种种，在原位HepG2异种移值物小鼠中，口服方式液药能力化性DOX·HCl脂质体比DOX·HCI和DOX·HCl脂质体更具更强的抗肺部肿癌效果，但在皮下组织H22异种移值物鼠中，其抗肺部肿癌效果与DOX·稀盐酸脂质体类似于。在进步的概述中，口服方式液药能力化性DOX·HCl脂质机制剂后，心房和肾脏渗透性更为明显降低。迄今为止的统计资料表达，口服方式液药能力化性DOX·HCl脂质体可不断增加肝靶向疗法性，展示 仰制异种移值物肺部肿癌的优秀药用价值，并应对有效的心房和肾脏渗透性。有关的选择：DSPE-PEG-FITCDSPE-PEG-FolateDSPE-PEG-IADSPE-PEG-MalDSPE-PEG-NH2DSPE-PEG-NHSDSPE-PEG-OHDSPE-PEG-propargylDSPE-PEG-AlkyneDSPE-PEG-Rhodamine专利权证明函：本公司随着有关于东西科技创新中文核心期刊参考文献、新教材和平台网站编译整体的东西，仅应用于对有关于东西地理学视频的了解、点赞和课堂教育教育或地理学探析。予以版权侵权，请找我门误删。