DSPE-PEG-FA修饰语nm顆粒适用于强化*细胞核摄入与核算位发挥超链接：//pubs.acs.org/doi/abs/10.1021/acsami.5b05038小说作家：杨丽，林金艳，杨瑞祥，李彦修，吴世超，玉皇，叶社芳，谢丽娅，戴理宗，侯真庆提要：组合丝裂霉素C (MMC)–磷脂结合物可挺高类药包封率并降低类药早点施放、DSPE-PEG-DHA (DSPE-PEG-FA) 需用于特喜欢的人靶点口服药剂*的优越，.我有关资料一个多种简易的一锅自折装路线地图来制取放有MMC–磷脂结合物的DSPE-PEG基nm颗料 (MP-PEG-FA NPs)。共聚交影像和流式的癌人体细胞膜核术均体现了，在癌人体细胞膜核摄取量和癌人体细胞膜核内类药递送后，MMC布置到癌人体细胞膜核核中。更必要的是，混身给药的MP-PEG-FA NPs可上升HeLa*裸鼠的血管坚持下去性和促进的*蓄积。本的研究了解一个多种简易有效地的机制来设置源于*癌类药–磷脂结合物的靶点口服药剂类药递送整体，以达到持续时间/设定的类药施放。译文翻译：Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.

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