论文：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy期刊论文外链：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205编辑：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su绪论：AimWe designed acid-labile methotrexate (MTX) targeting prodrug self-assembling nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi-chemotherapeutic drugs and combination cancer therapy.MethodsA dual-acting MTX, acting as both an anticancer drug and as a tumor-targeting ligand, was coupled to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[aldehyde(polyethylene glycol)-2000] via Schiff’s base reaction. The synthesized prodrug conjugate (DSPE-PEG-Imine-MTX) could be self-assembled into micellar nanoparticles (MTX-Imine-M) in aqueous solution, which encapsulated CUR into their core by hydrophobic interactions (MTX-Imine-M-CUR).

最后备制的MTX-Imine-M-CUR奈米颗粒状由的内部疏水DSPE/CUR主导和静态亲水双羟基聚乙二醇（PEG）金属护壳分解成，金属护壳含有自靶向疗法MTX前药冠。1,2-二硬脂酰-sn-甘油-3-磷酸乙酰胺-N-[醛（聚乙二醇）-2000]和MTX间的亚胺进行连接体充当情况共价键，大量强，所有在含偏酸pH下迅速裂解，在生理性pH下依然增加完整详细。MTX-imine-M-CUR不错进行备孕叶酸肾上腺素受体介导的内吞效果确定性效果地将MTX和CUR识别码到癌症复发細胞中，自后进行内体/溶酶体的含偏酸迅速施放CUR和吸附性形势的MTX。于此，MTX-Imine-M-CUR在身体和身体的*癌抗逆性凸显低过pH不敏感性的电机载荷CUR的DSPE-PEGAmide-MTX組裝纳米技术技术粉末状（MTX-Amide-M-CUR）、电机载荷CUR（M-CUR）的MTX非偶联DSPE-PEG組裝胶束纳米技术技术粉末状、二者自由中药的乐队组合和每个自由中药。想关推建：TAT-PEG-DSPECy3-iRGD-PEG-DSPEFITC-iRGD-PEG-DSPER8-PEG-DSPEAngiopep-2-PEG-DSPEFITC-Angiopep-2-PEG-DSPETH-PEG-DSPER6H4-PEG-DSPE这些文章标题方式特征当下学术期刊或文献资料，若有知识产权侵权请找话题让我们删除图片！