论文资料：Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer期刊论文地址：//www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.575365/full小说作者：Jun Shao&#x;Jun Shao1†Xiaoming Zheng&#x;Xiaoming Zheng1†Longbao FengLongbao Feng2Tianyun LanTianyun Lan3Dongbing DingDongbing Ding1Zikai CaiZikai Cai1Xudong ZhuXudong Zhu1Rongpu LiangRongpu Liang1Bo Wei*Bo Wei1*

As shown in Scheme 1, first, DSPE-PEG-RGD was obtained based on the Michael addition reaction between RGD peptide and DSPE-PEG-Mal. Second, the NIR agent ICG was encapsulated by the DSPE-PEG-RGD matrix via the self-assembly method. DSPE-PEG-Mal is an amphiphilic polymer. PEG serves as a hydrophilic unit to form the shell while DSPE is a hydrophobic unit to form the hydrophobic cavity with ICG in the core. The synthesis and Characteristics of DSPE-PEG-RGD@ICG were analyzed, including 1H NMR spectroscopy, transmission electron microscope (TEM), and so on. Then, the cellular uptake and biocompatibility were assessed. In addition, by using an optical imaging system, we observed the biodistribution and improved accumulation of DSPE-PEG-RGD@ICG in the tumor. The results of this study may provide a promising nanocarrier to realize the future clinical application of optical molecular imaging in early diagnosis and accurate resection of GC.

应先，根据RGD肽和DSPE-PEG-Mal之中的Michael加上反应迟钝才能得到DSPE-PEG-RGD。另外，利用自安装的方法已近红外采血管ICG包封在DSPE-PEG-R GD栽培基质中。DSPE-PEG-Mal是一个种两亲性聚合反应物。PEG作亲水机组养成塑料壳，而DSPE作疏水机组养成疏水腔，ICG靠近中心。炼制简述特质DSPE-PEG-RGD@ICG在1H NMR光谱图、散射电子元器件光学显微镜（TEM）等实行介绍，第三考核神经元摄取量和生态学相融性。不仅，完成利用光电技术激光散斑软件系统，他们看了DSPE-PEG-RGD@ICG在恶性肿瘤中。本设计的最终结果概率为改变光电技术碳原子激光散斑在GC早评估和较准肿瘤切除中的未來临床研究运用供应有发展潜力的納米各种载体。

一些推建服务：TH-PEG-DSPER6H4-PEG-DSPEMPG-PEG-DSPEGE11-PEG-DSPEPTP-PEG-DSPESP94-PEG-DSPET7(HAIYPRH)-PEG-DSPEOctreotide-PEG-DSPEYIGSR-PEG-DSPEAPRPG-PEG-DSPENGR-PEG-DSPE以内小文章內容渠道以及中文核心期刊或学术论文，若有侵权案请结合我们公司删除图片！