资料：PLGA-卵磷脂-PEG核壳纳米级离子于肝癌靶向疗法*网页链接：//www.worldscientific.com/doi/abs/10.1142/S1793984411000359作著：光鲜亮丽， 里克·奥克塔维安蒂·托伊普， 陶鹏， 和 林诗琳提要：我门公司消息新一种多用途聚乳酸-工业酒精酸共聚物 (PLGA)-卵磷脂-聚乙二醇 (PEG) 核壳nm技术塑料再生粉末 (NPs)，该nm技术塑料再生粉末颇具脂质体和混物物nm技术塑料再生粉末的长处，要用于递送肿瘤放疗化疗药剂治疗。该nm技术塑料再生粉末的比单单从单单从表面积、单单从单单从表面正电荷和单单从单单从表面官能团可根据不同的秘方参数表枯燥控制，且重叠性好，这类脂质/混物物、1,2-二硬脂酰-sn-甘油-3-磷酸工业酒精胺 (DSPE)-PEG- COOH /卵磷脂、DSPE-PEG- COOH /DSPE-PEG- NH 2 的重量比已经 DSPE-PEG 端基的掩盖。我门公司将模形肿瘤放疗化疗药剂治疗——亲丙烯酸乳液顺铂 (DDP) 或疏丙烯酸乳液 DDP 前药——封装类型于nm技术粉末 (NP) 中，结果彰显彰显其包封率高、比较稳定处理佳、对高 FA 感觉表明的 MCF-7 组织血细胞含有特喜欢的人靶向治疗治疗识别图片的能力，且 FA 感觉表明量高，且组织血细胞毒副作用较小。某些 PLGA-卵磷脂-PEG 核壳nm技术粉末 (NP) 已被单位证明是一个种*具潜力股的肺癌靶向治疗治疗*药剂治疗递送nm技术媒体。Abstract：Protein cages have been widely investigated as molecular drug carrier. E2 protein from Bacillus stearothermophillus forms a dodecahedral cage structure of approximately 24 nm in diameter. To formulate a sustainable release profile, E2 protein was further encapsulated into poly(lactide-co-glycolide) (PLGA) microparticles to form a composite structure using water-in-oil-in-water (W/O/W) double emulsion method. The influence of fabrication parameters on microparticle morphology and E2 protein release profile were investigated. The microparticle size increased when the stirring speed of the second emulsification decreased. Decrease in the volume of external aqueous phase led to the reduction of microparticle size without affecting its porosity. The higher ionic concentration of external aqueous phase in the presence of surfactant resulted in microparticles with closed pores on surface. Increase in polymer concentration also led to the formation of less porous microparticles. The E2 protein was not dissociated upon encapsulation into PLGA microparticles based on the unchanged particle size of E2 protein. E2 protein release was studied in phosphate-buffered saline solution at 37°C. The initial burst and release rate were lowered as the surfactant concentration in external water phase during the fabrication process was increased from 0.1% to 1% (w/v). After 14-day incubation, no observable polymer degradation was found while the surface of microparticles appeared to be smoother than before incubation.

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