期刊论文：线粒体、溶酶体和内质网：那种是光疗的适宜靶点？的链接：//www.sciencedirect.com/science/article/abs/pii/S0168365922006320小说作者：李艳红 ，贾浩然 ，王洪 银，华先武 ，鲍彦文 ，吴福 根节选：小结光发动机手术医治(PDT) 也是种有力的胃癌手术医治的方式，其亚内部影响位点的确切无误度超空间就能控制对其就能性至关重点。以至于，确切无误十分有差异内部器靶点医疗法法 PDT 机制的成效极具挑戰性，因此不易找见另一个从单一的软件就能保证对有差异内部器的设定靶点医疗法法性、可剥离的日期窗和类同的融入量。这里，你们将二氢卟酚 e6 (Ce6) 与 1,2-二硬脂酰-sn-甘油-3-磷酸乙酸乙酯胺-N- [氨基(聚乙二醇)-5000]（铵盐）（DSPE-PEG 5000 -NH 2）偶联受到 DSPE-PEG-Ce6，其在内部内化后能从线粒体迁入到溶酶体，结果是到内质网 (ER)。归功于DSPE-PEG-Ce6亚内部分布图制作的动图性并且其与内部器融入量的能自由调节性，你们确切无误地选择了该大分子的光发动机手术医治（PDT）成效步骤，即线粒体 > 内质网 > 溶酶体。本科研明确提出了另一个佳的整治软件，可以于确切无误考核既定内部器靶点医疗法法的光发动机手术医治（PDT）成效，并有机会提高网站以后就能光发动机手术医治机制的发展方向。AbstractPhotodynamic therapy (PDT) is a robust cancer treatment modality, and the precise spatiotemporal control of its subcellular action site is crucial for its effectiveness. However, accurate comparison of the efficacy of different organelle-targeted PDT approaches is challenging since it is difficult to find a single system that can achieve separate targeting of different organelles with separable time windows and similar binding amounts. Herein, we conjugated chlorin e6 (Ce6) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (ammonium salt) (DSPE-PEG5000-NH2) to afford DSPE-PEG-Ce6, which could migrate from mitochondrion to lysosome and ultimately to endoplasmic reticulum (ER) after cellular internalization. Benefiting from the dynamic subcellular distribution of DSPE-PEG-Ce6 with tunable organelle-binding amounts, we accurately determined the PDT efficacy order of the molecule, i.e., mitochondrion > ER > lysosome. This work proposes an ideal model system for accurately evaluating the specific organelle-targeted PDT efficacy and may promote the future development of effective PDT strategies.

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