专著：PLGA–LECITHIN–PEG CORE-SHELL NANOPARTICLES FOR CANCER TARGETED THERAPY期刊论文图片链接：//www.worldscientific.com/doi/abs/10.1142/S1793984411000359作家：MINGBIN ZHENG, PING GONG, DONGXUE JIA, CUIFANG ZHENG, YIFAN MA, and LINTAO CAI

We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG-COOH/lecithin, DSPE-PEG-COOH/DSPE-PEG-NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA–lecithin–PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.

多的功能聚乳酸-羟基乙酸共聚物（PLGA）-卵磷脂-聚乙二醇（PEG）核壳納米水塑料再生颗粒（NP）的开放，该納米水塑料再生颗粒构建了脂质体和汇聚物NP的很有益的特点，使用于中成药的传输。经由繁多成份性能指标，如脂质/聚合反应物、1,2-二硬脂酰基-sn-甘油-3-磷酸甲醇胺（DSPE）-PEG-COH/卵磷脂、DSPE-PEG-COOH/DSPE-PEG-NH2产品品质比和DSPE-PEG后部基团的装饰，粒度分布、外面自由电荷和外面官能团很轻松以非常可反复的习惯来调接。各位将建模放疗化疗中成药亲水性聚氨酯树脂顺铂（DDP）或疏水性聚氨酯树脂DDP前药封口形式在NP中，并表现出高封口形式的效率、优良的比较平稳性处理、对MCF-7受损内部的特情人FA靶点识別，都具有过FA感觉表明和相当的的受损内部致癌性。这般PLGA–卵磷脂–PEG核壳微米级粒子束（NP）被证件就是种很有前程的肠癌靶点根治中成药递送微米级平台。有关建议：DSPE-PEG-Cy7DSPE-PEG-cRGDDPPE-PEG-cRGDDMPE-PEG-cRGDDOPE-PEG-cRGDDPPE-PEG-RGDDMPE-PEG-RGDDOPE-PEG-RGD4-Arm PEG-DSPEC12-PEG-COOHC18-PEG-COOH

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