论文资料：说明脂质体分裂的控制力：外界扰动和化学物质自己的亲和力链接搜索：//pubs.acs.org/doi/abs/10.1021/la300127m我们：王曦，马修·M·辛德尔，王思文，雷吉娜·拉根文献综述：能通过反义寡脱氧核苷酸 (AS-ODN) 或小打扰 RNA (siRNA) 保健法做好使用性DNA调节现已*传统式肿瘤药物无非根冶的常见疾病。所以，反义保健法随着在身体液中的不稳定性可靠能力差和上皮细胞膜内摄取量限制而遭受的阻碍。为了更好地解決这类故障 ，我们大家实验设计室制作一个多种配体靶点疗法和前景不稳定性可靠的纳米级小粒药品。人间肺腺癌上皮细胞膜大多数过描述 σ 肾上腺素受体，那么能用对应配体（举例茴香酰胺）做好靶点疗法*。将对于人间长期生存素的 AS-ODN 或 siRNA 与平台 DNA（大牛胸腺 DNA）混杂，再与鱼精血清（是一种带高正正电荷的肽）复合型。将换取的粒状剂用由 DOTAP 和热量（摩尔比 1:1）构成的的阳阴阴阳阴离子型脂质体包被，以换取 LPD（脂质体-聚阳阴阴阳阴离子型-DNA）微米粒状剂。接着，用后插入图法将预制构件的LPD微米物体与DSPE-PEG-茴香酰胺（我们大家科学微生物实验室所以，金星由于这些原因发展的那种PEG化配体脂质）一个孵育，加入配体靶向药物治疗性和前景不稳性。互相光催化原理了DSPE-PEG发泡密封条的非靶向药物治疗微米物体最为相较比较。实施Survivin mRNA下跌、Survivin核蛋白下跌、产生*生殖血人体组织细胞核凋亡的技能、*生殖血人体组织细胞核种植抑制用处各类净化处理后的*生殖血人体组织细胞核对*癌制剂的化学上的增敏用处来分析奈米塑料再生颗粒的反义特异性。咱们看到，PEG化奈米塑料再生颗粒的*生殖血人体组织细胞核递送和反义特异性是回文序列依赖性关系性的，另外依赖性关系于茴香酰胺配体的具备。靶向疗法疗法PEG化奈米塑料再生颗粒对寡核苷酸的摄食可能会会被超量的矿酸配体寡头垄断。咱们的结杲表面，配体靶向疗法疗法和前景相对稳定的奈米塑料再生颗粒可以抉择性地将 AS-ODN 和 siRNA 递邮到癌症生殖血人体组织细胞核中实施*。AbstractAbstract ImageAtomic force microscopy (AFM) studies under aqueous buffer probed the role of chemical affinity between liposomes, consisting of large unilamellar vesicles, and substrate surfaces in driving vesicle rupture and tethered lipid bilayer membrane (tLBM) formation on Au surfaces. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-poly(ethylene glycol)-2000-N-[3-(2-pyridyldithio) propionate] (DSPE-PEG-PDP) was added to 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles to promote interactions via Au–thiolate bond formation. Forces induced by an AFM tip leading to vesicle rupture on Au were quantified as a function of DSPE-PEG-PDP composition with and without osmotic pressure. The critical forces needed to initiate rupture of vesicles with 2.5, 5, and 10 mol % DSPE-PEG-PDP are approximately 1.1, 0.8, and 0.5 nN, respectively. The critical force needed for tLBM formation decreases from 1.1 nN (without osmotic pressure) to 0.6 nN (with an osmotic pressure due to 5 mM of CaCl2) for vesicles having 2.5 mol % DSPE-PEG-PDP. Forces as high as 5 nN did not lead to LBM formation from pure POPC vesicles on Au. DSPE-PEG-PDP appears to be important to anchor and deform vesicles on Au surfaces. This study demonstrates how functional lipids can be used to tune vesicle–surface interactions and elucidates the role of vesicle–substrate interactions in vesicle rupture.

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