学术论文：脂质聚丁二烯亚胺结合在一起物为CpG寡脱氧核苷酸菌物相融性形式对巨噬生殖细胞的评估微信链接：//link.springer.com/article/10.1007/s12257-020-0366-1原作者：杨智媛，崔恩瑞，尤佳妍&穆慧静节选：上述情况CpG寡脱氧核苷酸（CpG）体现了强的抗体力系统激刺意义，開發建设CpG媒体是完成高效率的性率癌症复发抗体力系统*的先决因素。本学习将1,2-二硬脂酰-sn-甘油-3-磷酸无水乙醇胺-N-[羟基虎珀酰亚胺（聚乙二醇）] (DSPE-PEG-NHS) 与聚氯乙烯亚胺 (PEI) 偶联，開發建设出的一种PEI-PEG-DSPE偶联物，需用为业物相匹配性的高效率的性率CpG媒体。我们都開發建设了四种PEIPEG-DSPE偶联物，每张偶联物的PEI大分子量有差异，DSPEPEG的体现层度也有差异，均主要表现出不错较低的体组织上皮生殖神经元致癌性。具有来讲，与进行天然水PEI递送CpG相对，以摩尔比0.1递送PEI (25 kDa)-PEG-DSPE和DSPE-PEG-NHS/（PEI的胺基）可造成RAW264.7体组织上皮生殖神经元对CpG的释放更高一些，这很有可能是是由于存有疏水脂质组成部分。虽然，PEI-PEG-DSPE/CpG和好材料物可诱发RAW264.7体组织上皮生殖神经元不错分秘体组织上皮生殖神经元因素（TNF-α），其意义与PEI/CpG和好材料物相对。由于，PEI-PEG-DSPE偶联物需用为业物相匹配性的高效率的性率媒体，将抗体力系统激刺剂CpG递送进巨噬体组织上皮生殖神经元。AbstractConsidering the potent immune stimulation by CpG oligodeoxynucleotides (CpGs), the development of CpG carriers is a prerequisite for efficient cancer immunotherapy. In this study, we conjugated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[hydroxyl succinimidyl (polyethylene glycol)] (DSPE-PEG-NHS) with polyethylenimine (PEI) to develop a PEI-PEG-DSPE conjugate that can serve as a biocompatible and efficient CpG carrier. Five types of PEIPEG-DSPE conjugates were developed, each with different molecular weights of PEI and different degrees of DSPEPEG modification, and all exhibited significantly lower cytotoxicity. In particular, compared to CpG delivery via natural PEI, delivery with PEI (25 kDa)-PEG-DSPE and DSPE-PEG-NHS/(amine groups of PEI) at a molar ratio of 0.1 resulted in a higher uptake of CpGs into RAW264.7 cells, probably because of the presence of a hydrophobic lipid moiety. In addition, PEI-PEG-DSPE/CpG complexes triggered significant cytokine secretion (TNF-α) from RAW264.7 cells, comparable to that triggered by PEI/CpG complexes. Thus, PEI-PEG-DSPE conjugates could serve as biocompatible and efficient carriers of the immune stimulator CpG to the macrophages.

北京pg电子娱乐游戏app 生物学带来了相应产品的：DSPE-PLGAcRGD(c[RGDfc])-PEG-DSPEDSPE-PEG-THRPPMWSPVWP（二硬脂酰基磷脂酰无水乙醇胺-聚乙二醇-转铁蛋白酶靶向治疗肽)C18-PEG-COOHCPP-PEG-DSPEm-PEG12-DSPEDSPE-PEG-CCK8mPEG-DMPE之上小文章内部來源各种各样期刊论文或文献综述，如无图片侵权请联系起来我们的册除！