mPEG-DSPE/阿霉素胶束的制备及其淋巴结转移治疗效果研究
文献综述：MPEG-DSPE聚合反应物胶束应用在淋疤结节结适当转移的经淋疤结节化疗药友链：//www.sciencedirect.com/science/article/abs/pii/S0378517315002902作家：雪莉，董 青，严志强，维岳 路，冯小编，曹 协 阿，谢作旭，苏冰霞，刘 敏阿节选：本理论研究制得了甲基聚乙二醇-二硬脂酰磷脂酰工业乙醇胺/阿霉素（MPEG-DSPE/DOX）胶束在使用*淋疤结转变。制得的MPEG-DSPE/DOX胶束呈圆形，孔径为20 ± 5nm。A375血癌细胞系系对DOX和MPEG-DSPE/DOX胶束的摄入率对应为51.2%和88.7%。RAW264.7血癌细胞系系对MPEG-DSPE/罗丹明B胶束的摧毁率比单个在使用罗丹明B低17.2倍。肉里集体填充器后，MPEG-DSPE胶束经淋疤管吸收的作用，在腘窝淋疤结中积聚。 MPEG-DSPE/DOX胶束较单个DOX能显著调低填充器位置肉里集体集体的破损。实现A375血癌细胞系系淋疤结转变裸鼠仿真模型，肉里集体填充器后，MPEG-DSPE/DOX胶束组腘窝淋疤结和髂窝淋疤结总重均显著少于生物学食盐水组和DOX组。MPEG-DSPE/DOX胶束能合理有效伤害性腘窝淋疤结和髂窝淋疤结中的*血癌细胞系系。总而言之所写，MPEG-DSPE胶束也是种很有发展趋势的*淋疤结转变的口服药物递送软件。 AbstractLymph node metastasis is one of the major pathways for tumor formation and it is difficult to deliver chemotherapeutics at therapeutic concentrations to lymph node metastasis. This study prepared methyl poly(ethylene glycol)-distearoylphosphatidylethanolamine/doxorubicin (MPEG-DSPE/DOX) micelle for the treatment of lymph node metastasis. The MPEG-DSPE/DOX micelle prepared were of spherical morphology with a particle size of 20 ± 5 nm. The uptake rates of DOX and MPEG-DSPE/DOX micelle by A375 cells were 51.2% and 88.7%, respectively. The phagocytosis rate of MPEG-DSPE/Rhodamine B micelle by RAW264.7 cells was 17.2-fold lower than for Rhodamine B alone. After subcutaneous injection, MPEG-DSPE micelle underwent lymphatic absorption and accumulated in popliteal lymph nodes. MPEG-DSPE/DOX micelle significantly alleviated damage to the subcutaneous tissue of the injection sites compared with DOX alone. We established a model of nude mice bearing lymph node metastasis of A375 cells. After subcutaneous injection, the weights of both the popliteal and iliac lymph nodes of the MPEG-DSPE/DOX micelle group were significantly lower than in the saline and DOX groups. MPEG-DSPE/DOX micelle effectively killed the tumor cells in popliteal and iliac lymph nodes. In conclusion, MPEG-DSPE micelle is a promising drug delivery system for the treatment of lymph node metastasis.
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