学术论文：BioMed Research International文章连接：//onlinelibrary.wiley.com/doi/full/10.1155/2014/129458结语：Postmodification of the liposome surface by amine-carboxyl conjugation (Figure 1(b)) was recently reported to overcome the rapid systemic clearance of D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone short peptide (PPACK), an antithrombin agent [30]. Palekar et al.  demonstrated that PPACK peptide is attached to the surface of preformed liposomes composed of EPC, DPPE, and DSPE-PEG2000-COOH (94 : 4 : 2 molar ratio) by applying standard amine-carboxyl coupling conditions for conjugating the N-terminus of the peptide to preformed carboxy-terminated DSPE-PEG-containing liposomes. The peptide was conjugated to the unilamellar liposomes and liposomes were purified by dialysis for four hours, which suggests high stability of the nanosystem. 

依据胺羧基偶联对脂质表皮面做后淡化，可能克服害怕抗凝血功能酶剂D-苯丙氨酰-L-脯氨酰基-L-精氨酰氯甲基酮短肽（PPACK）的高速 身体去除。Palekar等依据app规则胺羧基偶联标准将肽的N端偶联到提前达成的含羧基封鍴的DSPE-PEG的脂质体上，声明书了PPACK肽衔接在由EPC、DPPE和DSPE-PEG2000-COOH（94:4:2摩尔比）构成的提前达成的脂质体的外观上。肽与一层脂质体运用，脂质体依据透析4h纯化，这反映出纳米技术体系有着很高的稳固性。有关的强烈推荐：C18-PEGn-MaleimideC18-PEGn-N3 (N3: Azide)C18-PEGn-NH2 (NH2: Amine)C18-PEGn-NHSC18-PEGn-OHC18-PEGn-OPSSC18-PEGn-SH (SH: Thiol)mPEG-Cholesterol (mPEG-CLS)mPEG-CONH-C12mPEG-CONH-C16mPEG-CONH-C18之内散文知识起源四种论文期刊或资料，假如有侵权行为请保持联系当我们删除图片！