文献综述：Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles小编：Limei Han,Qiushi Yang,Teng Shen,Jin Qing &Jianxin Wang文献资料图片链接：//www.tandfonline.com/doi/full/10.3109/10717544.2015.1028600#abstractObjective: The formulation of polymer micelle was developed for probucol to improve its intestinal lymphatic transport.Materials and methods: Methoxy-polyethylenelglycol-distearyl phosphatidyl-ethanolamine (mPEG-DSPE) polymer was chosen to develop the micelles for probucol. The physicochemical properties were characterized. Caco-2 cell model, unconscious and conscious lymph duct cannulated rat models were established for in vitro and in vivo evaluation of lymphatic transport.Results: In vitro evaluation in the Caco-2 cell model showed that the micellar formulation could significantly increase the uptake and transport of probucol. The study in unconscious and conscious lymph duct cannulated rat models further verified the significant enhancement of lymphatic transport of probucol by mPEG-DSPE micelles.Discussion and conclusion: These results suggested that mPEG-DSPE micellar formulation could provide a useful alternative approach for improving the lymphatic transport of hydrophobic compounds.

的目的：制造技术普罗布考高聚物物胶束注射剂，以优化其消化道淋巴结集运。涂料和策略：首选甲氧基聚乙二醇二硬脂基磷脂酰无水乙醇胺（mPEG-DSPE）缔合物规划设计普罗布考胶束。对其化学实验操作本质特征对其进行了表现。制定Caco-2受损细胞模板工具、不经了解和有了解腮腺管插管大鼠模板工具，用作体内的和体内的腮腺运送评价。最终结果：在Caco-2肿瘤细胞模式化中的体内测试证明，胶束药物还可以同质性加入普罗布考的摄食和转化。在不想识和认识到淋疤管插管大鼠模式化中的实验进1步表明了mPEG-DSPE胶束对普罗布考淋疤转化的同质性资料。计划方案和报告：一些报告证明，mPEG-DSPE胶束药品可以为改进疏水单质的淋疤集运出具这种有所帮助的替换具体方法。相关的安利：Cy7-PEG-DPPEDSPE-PEG-Cy7DSPE-PEG-cRGDDPPE-PEG-cRGDDMPE-PEG-cRGDDOPE-PEG-cRGDDPPE-PEG-RGDDMPE-PEG-RGDDOPE-PEG-RGD4-Arm PEG-DSPE左右一篇文章玩法由来种类刊物或文章，予以版权侵权请连系人们删掉！