学术论文：Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles写作者：Limei Han,Qiushi Yang,Teng Shen,Jin Qing &Jianxin Wang期刊论文外链：//www.tandfonline.com/doi/full/10.3109/10717544.2015.1028600#abstractObjective: The formulation of polymer micelle was developed for probucol to improve its intestinal lymphatic transport.Materials and methods: Methoxy-polyethylenelglycol-distearyl phosphatidyl-ethanolamine (mPEG-DSPE) polymer was chosen to develop the micelles for probucol. The physicochemical properties were characterized. Caco-2 cell model, unconscious and conscious lymph duct cannulated rat models were established for in vitro and in vivo evaluation of lymphatic transport.Results: In vitro evaluation in the Caco-2 cell model showed that the micellar formulation could significantly increase the uptake and transport of probucol. The study in unconscious and conscious lymph duct cannulated rat models further verified the significant enhancement of lymphatic transport of probucol by mPEG-DSPE micelles.Discussion and conclusion: These results suggested that mPEG-DSPE micellar formulation could provide a useful alternative approach for improving the lymphatic transport of hydrophobic compounds.

目的意义：成功研制普罗布考缩聚物胶束中药制剂，以提高其肠管淋疤装运。装修材料和技巧：确定甲氧基聚乙二醇二硬脂基磷脂酰酒精胺（mPEG-DSPE）缔合物研发普罗布考胶束。对其化学质地做了分析方法。设立Caco-2神经细胞型号、被人识和有发觉淋疤管插管大鼠型号，用以身体和身体淋疤装运评价。最终结果：在Caco-2细胞系三维模型工具中的离体考评是因为，胶束剂型能够相关系数新增普罗布考的摄入和装运。在无道德观念识和道德观念腮腺管插管大鼠三维模型工具中的设计进一次可确认了mPEG-DSPE胶束对普罗布考腮腺装运的相关系数不断增强。研讨会和依据：这类最终结果反映出，mPEG-DSPE胶束注射剂能能为可以改善疏丙烯酸乳液化学物质的淋巴结轉運供给一款实用的混用做法。有关系引荐：Cy7-PEG-DPPEDSPE-PEG-Cy7DSPE-PEG-cRGDDPPE-PEG-cRGDDMPE-PEG-cRGDDOPE-PEG-cRGDDPPE-PEG-RGDDMPE-PEG-RGDDOPE-PEG-RGD4-Arm PEG-DSPE超过篇文章介绍来源地各种类型学术期刊或文献综述，如不侵犯著作权请连接我卸载！