学术论文：Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells小编：T Ishida a 1, M.J Kirchmeier a 2, E.H Moase a, S Zalipsky b, T.M Allen 参考文献联接：

英文论文：DOPE liposomes can also be stabilized in the bilayer state by an amphiphile with bulky and/or charge-repulsing hydrophilic moieties [35]. CHEMS (cholesteryl hemisuccinate), which is net negatively charged at pH 7.4, has been widely used to stabilize DOPE in the bilayer state at neutral pH. Protonation of CHEMS at low pH (<6.0) accelerates the destabilization of DOPE vesicles by promoting the formation of the hexagonal (HII) phase [16], [36]. DOPE/CHEMS formulations without mPEG-DSPE had little leakage at pH 7.4, but rapidly released encapsulated dye at pH 5.5 (Fig. 2A). At pH 5.5 or 7.4 less than 10% leakage occurred over 24 h when these liposomes were stabilized with 5 mol% mPEG-DSPE (Fig. 2A). In the presence of DTT, DOPE/CHEMS liposomes containing 5 mol% mPEG-S-S-DSPE had a release half-life of approximately 8 h at pH 5.5, while little release occurred at pH 7.4 (Fig. 2B); DTT treatment of DOPE/CHEMS liposomes stabilized with 3 mol% mPEG-S-S-DSPE resulted in intermediate leakage rates

DOPE脂质体也会依据体现了大体上积和/或自由带电粒子反感亲水个部分的两亲性物在加厚的情形下平衡可靠。CHEMS（高密度脂蛋白半虎珀酸盐）在pH 7.4时带净负自由带电粒子，已被常见代替在碱性pH下平衡可靠加厚的情形的DOPE。CHEMS在低pH（<6.0）下的质子化经过带动六方（HII）相的成型1了DOPE囊泡的失稳。可含mPEG-DSPE的DOPE/CHEMS药品在pH 7.4时可以说还没有透漏，但在pH 5.5时发展挥发包封染剂。

在pH 5.5或7.4下，当这些脂质体用5mol%mPEG-DSPE稳定时，24小时内发生的泄漏小于10%。在DTT存在的情况下，含有5mol%mPEG-S-S-DSPE的DOPE/CHEMS脂质体在pH 5.5时的释放半衰期约为8小时，而在pH 7.4时几乎没有释放（图2B）；用3mol%mPEG-S-S-DSPE稳定的DOPE/CHEMS脂质体的DTT处理导致中等泄漏率。

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