论文参考文献：Biotin-conjugated PEGylated porphyrin self-assembled nanoparticles co-targeting mitochondria and lysosomes for advanced chemo-photodynamic combination therapy†原作者：Baskaran Purushothaman , Jinhyeok Choi , Solji Park , Jeongmin Lee , Annie Agnes Suganya Samson , Sera Hong and Joon Myong Song文献综述连接：  In this study, biotin-conjugated PEGylated photosensitizer (PS) self-assembled nanoparticles (meso-tetraphenylporphyrin (TPP)–PEG–biotin SANs) were prepared via a self-assembly process to serve as nanocarriers for chemo-drugs as well as PSs. Electron microscopy results reveal the spherical shape of the nanoparticles (NPs). In the NPs, conjugated biotin plays a key role in selective tumor targeting. In vitro cellular experiments revealed the rapid cellular uptake of the TPP–PEG–biotin conjugates by MCF-7 cells that overexpress the biotin receptor, and verified that the conjugates were much more effective PSs than TPPS used as control in the cytotoxicity test. Interestingly, subcellular localization studies showed that the conjugates and their self-assembled NPs were localized mainly in mitochondria and partially in lysosomes, whereas TPPS was localized only in lysosomes. With the exclusive localization in mitochondria, high-content cell based assay showed that the TPP–PEG–biotin SANs induced rapid mitochondrial membrane potential transition (MPT), leading to cellular apoptosis. The chemo-drug doxorubicin (DOX) was successfully encapsulated in the TPP–PEG–biotin SANs (DOX@TPP–PEG–biotin) and had synergistic effects with enhanced cytotoxicity after PDT action. 

在一项探讨中，进行自折装时候备制了怪物素偶联的聚乙二醇化光敏剂（PS）自折装微米颗粒（meso-四苯基卟啉（TPP）-PEG-怪物素-SAN），作无机化学类药物和PS的微米膜蛋白。微显微镜观察但是显现了纳米技术阿尔法粒子（NP）的球状。在NP中，共轭生态学素在采用性癌肿靶向疗法中起着最为关键的的作用。体内神经神经神经元研究呈现了过多表明生态学素肾上腺素受体的MCF-7神经神经神经元对TPP-PEG-生态学素偶联物的迅速的神经神经神经元摄取量，并认可了偶联物比较用作神经神经神经元渗透性经过多次实验发现比的TPPS更有用。亚上皮人体神经元产品手机导航地位深入分析说明，偶联物以及自組裝NP注意产品手机导航地位一直在线视频粒体中，大部分产品手机导航地位在溶酶体中，而TPPS仅产品手机导航地位在溶酶体。高含氧量上皮人体神经元检测工具说明，TPP-PEG-海洋生物素SANs仅一直在线视频粒体中产品手机导航地位，可分析线粒体膜电势差迅速转变成（MPT），产生上皮人体神经元凋亡。化疗药肿瘤药物阿霉素（DOX）顺利封裝在TPP-PEG-海洋生物技术素SAN中(DOX@TPP-PEG-海洋生物技术素），并在PDT目的后具备着增强学习细胞核渗透性的融合目的。相应的网友推荐：ICG-PEG-AlkyneICG-PEG-BiotinICG-PEG-CHOICG-PEG-COOHICG-PEG-cRGDICG-PEG-FolateICG-PEG-MALICG-PEG-N3ICG-PEG-NH2ICG-PEG-NHSICG-PEG-OHICG-PEG-SH