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DSPE-PEG-RGD的合成与制备
发布时间:2025-07-14     作者:kx   分享到:
论文参考文献:靶向治疗递送包装康普瑞塔汀A-4和阿霉素的RGD遮盖脂质体在**:内和内科学研究下载链接://www.sciencedirect.com/science/article/abs/pii/S0939641110000044小说作家:张逸飞,王竣工,卞东彦,张 轩 ,刘军 节选:RGD–PEG-DSPE的合并DSPE-PEG-RGD 的备制方式方法如上根据上述 。对发生影响混和物在不一样時间点的色谱研究(图 1)表示,在发生影响条件下,RGD 近乎几乎所耗。发生影响制度中约 50% 的 DSPE-PEG-NHS 插入量与 RGD 肽构建。所得额物品不用办理进一歩纯化就可用来备制脂质体。Synthesis of RGD–PEG-DSPEPreparation of DSPE-PEG-RGD was performed as described previously [12]. Chromatographic analysis of the reaction mixture at different time points (Fig. 1) showed that the RGD was consumed almost completely under the conditions of reaction. Around 50% of input DSPE-PEG-NHS in reaction system was conjugated with RGD peptide. The resulting product was then used for preparing liposomes without further purification.

DSPE-PEG-RGD

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