医学文献：Biotin-conjugated PEGylated porphyrin self-assembled nanoparticles co-targeting mitochondria and lysosomes for advanced chemo-photodynamic combination therapy†小说家：Baskaran Purushothaman , Jinhyeok Choi , Solji Park , Jeongmin Lee , Annie Agnes Suganya Samson , Sera Hong and Joon Myong Song论文资料跳转：结语：The release pattern of DOX from the DOX@TPP–PEG–biotin self-assembled nanoparticles was evaluated by the dialysis method. In this experiment, the released sample was measured at different time points using HPLC. Fig. 2c shows the release of DOX from the self-assembled nanoparticles at 37 °C in different PBS media (pH 7.4 and pH 6.0), indicating desirable stability of the DOX@TPP–PEG–biotin SANs. After 24 h, the DOX released was only 30.0 ± 1.8% in the pH 7.4 PBS medium compared to that in the pH 6.0 PBS medium (65.4 ± 2.0%). These results indicate that under acidic conditions the DOX was released into the cellular medium. The sizes and zeta potentials in Fig. 2a and b showed no aggregation behavior at room temperature for five days at 37 °C, indicating that the self-assembled nanoparticles prepared in this study showed adequate stability.

DOX的脱离模试DOX@TPP经由透析法对PEG-菌物素自拆装nm塑料颗粒对其进行了评诂。在该實驗中，食用HPLC在多种的时间点检测脱离的产品的样品。展现了在37°C下，在各种的PBS材质（pH 7.4和pH 6.0）中，DOX从自拼装微米物体中挥发起来，揭示DOX还具有可靠性DOX@TPP–PEG–生物制品素SAN。24一小时后，与pH 6.0 PBS陪养基（65.4±2.0%）相对，pH 7.4 PBS陪养基中挥发的DOX仅为30.0±1.8%。这部分成果表示，在弱酸性状态下，DOX被发挥到上皮细胞培育基中。图2a和b中的图片尺寸和ζ电势在37°C的温度下连续式半个月未显现出聚集地行为表现，表示本论述中化学合成的自主装纳米级离子显现出充足的的不稳性。相应的介绍：PLGA(5K)-PEG-NHSY-shape-PEG-NHS4-ArmPEG-(3Alkyne-1NHS)4-ArmPEG-(3Biotin-1NHS)8-ArmPEG-(2ARM-NHS,6ARM-Biotin)Biotin-PEG-NHSBiotin-PEG4-S-S-NHSmPEG-SS-NHSNHS-PEG-NHSPDLLA(5K)-PEG-NHSPLGA(75:25)(5K)-PEG-NHSsulfo NHS-PEG-SS-PEG-NHS sulfo超过优秀文章项目来原各种类型论文期刊或专著，告之侵权商标请连系自己删了！