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SH-PEG-COOH自组装层提升皮质醇检测灵敏度
发布时间:2025-07-15     作者:zyl   分享到:
 文献综述:Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System小说作品:by Jingjing Liu 1,2,3ORCID,Ning Xu 2,Hong Men 2ORCID,Shuang Li 1ORCID,Yanli Lu 1,Sze Shin Low 1,Xin Li 1,Lihang Zhu 1,Chen Cheng 1,Gang Xu 1 andQingjun Liu专著地址: 英文论文:With the accelerated pace of life, non-invasive cortisol detection at the point of care (POC) is in high demand for personal health monitoring. In this paper, an ultrasensitive immunosensor using gold nanoparticles/molybdenum disulfide/gold nanoparticles (AuNPs/MoS2/AuNPs) as transducer was explored for non-invasive salivary cortisol monitoring at POC with the miniaturized differential pulse voltammetry (DPV) system based on a smartphone. Covalent binding of cortisol antibody (CORT-Ab) onto the AuNPs/MoS2/AuNPs transducer was achieved through the self-assembled monolayer of specially designed polyethylene glycol (PEG, SH-PEG-COOH). Non-specific binding was avoided by passivating the surface with ethanolamine. The miniaturized portable DPV system was utilized for human salivary cortisol detection. A series current response of different cortisol concentrations decreased and exhibited a linear range of 0.5–200 nM, the detection limit of 0.11 nM, and high sensitivity of 30 μA M−1 with a regression coefficient of 0.9947. Cortisol was also distinguished successfully from the other substances in saliva. The recovery ratio of spiked human salivary cortisol and the variation of salivary cortisol level during one day indicated the practicability of the immunosensor based on the portable system. 

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这篇文探讨好几个种适用金nm阿尔法水粒子/二混炼钼/金nm阿尔法水粒子(AuNPs/MoS2/AuNPs)身为调节器器的超敏锐抗体调节器器,用到立于智慧移动的家庭型差分输入脉冲伏安法(DPV)软件在POC去非破坏性口水真皮醇污染监测。真皮醇抗原(CORT-Ab)与AuNPs/MoS2/AuNPs感应器器的共价综合是顺利确认层次性设计方案的聚乙二醇(PEG,SH-PEG-COOH)的自拆装编织成单层保证的。顺利确认用乙酸乙酯胺钝化表面能来逃避非活性朋友综合。超小型携便式式DPV系统使用人间吐沫真皮醇论文检测。与众不同牛皮醇溶度的一种的直流电加载失败调低,平滑区间为0.5-200 nM,加测限为0.11 nM,精确度度为30μA M−1,归队因子为0.9947。牛皮醇也成功地与唾沫中的另一物资区分开而来。加标人唾沫牛皮醇的收集率和唾沫牛皮醇横向在在一天的内的转变 反映出了研究背景一体式式软件的免役感测器器的常见性。相关信息推荐英文:SH-PEG-HZACA-PEG-SHSH-PEG-OHAC-PEG-SHAlKyne-PEG-SHMA-PEG-SHN3-PEG-SHSH-PEG-BiotinFmoc-NH-PEG-SHSH-PEG-NH2.HClSH-PEG-COOH这些好文章内部因素种类学术期刊或医学文献,如果有抄袭请找他们删去!