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DSPE-PEG2000-NH₂修饰构建AFP靶向磁性荧光脂质体探针
发布时间:2025-07-15     作者:kx   分享到:
学术论文:甲胎核蛋白*体修饰语荧光带磁电极对HepG2人体细胞及*模式化小鼠的 论述外链://www.ingentaconnect.com/contentone/asp/jnn/2020/00000020/00000008/art00088小说作品:陈艳帆,卢江环,杨杰,郝凯旋,李敏节选:为在校园营销推广活动的环节之中所构建某种双靶向治疗治疗药物疗法(磁靶向治疗治疗药物疗法和*体靶向治疗治疗药物疗法)全智能性永磁铁荧光脂质体探头,该探头还有着很好的微生物工程相融性,对较早肝*的珍断还有着较高的特情人。称取1,2-二硬脂酰-sn-甘油-3-磷酸-无水乙醇胺-N- [氨基(聚乙二醇)](DSPE-PEG2000-NH2)与Cy7 N-羟基蜜腊酰亚胺酯(Cy7-NHS)通过化学化学反应,转化DSPE-PEG 2000 -Cy7。将鸡蛋卵磷脂、高胆固醇的食物、DSPE-PEG 2000 -Cy7和Fe 3 O 4先后加进到化学化学反应液中,合并荧光四空气腐蚀三铁(Fe 3 O 4)脂质体。将永磁铁脂质体(MLP)与甲胎蛋清(AFP)多克隆*体偶联,并对端部AFP*体淡化的永磁铁脂质体在人肝*癌组织HepG2和肝*建模 小鼠中的选用通过了讲解科学研究。荧光四空气腐蚀三铁脂质体呈圆形,平均值两相流扭矩学半径约150nm,带负正电荷。该荧光永磁铁探头对HepG2癌组织渗透性较小,并加强了AFP*体靶向治疗治疗药物疗法影像在肝*建模 小鼠肝*珍断中的特情人。肯定,AFP*体偶联的荧光永磁铁探头是某种很有发展前途的全智能性用具,还有着很好的微生物工程相融性,并还有着较高的灵敏性度和特情人,可以于药学*症的珍断和*。

DSPE-PEG2000-NH₂

To construct a dual-targeting (magnetic targeting and antibody targeting) multi-functional magnetic fluorescent liposome probe with a good biocompatibility and high specificity for early liver cancerdiagnosis. 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-[amino(polyethylene glycol)] (DSPE-PEG2000-NH2) and Cyanine7 N-hydroxysuccinimide ester (Cy7-NHS) were measured and reacted for forming DSPE-PEG2000-Cy7. Egg yolk lecithin, cholesterol, DSPE-PEG2000-Cy7 and Fe3O4 were added in orderly into the reaction solution for synthesis of fluorescent ferroferric oxide (Fe3O4) liposome. The Magnetic liposome (MLP) was coupled with Alpha-Fetoprotein (AFP) polyclonal antibody and the ending AFP antibody modified magnetic liposome was analyzed and studied on human hepatoma cell HepG2 and cancer model mouse. The fluorescent ferroferric oxide liposome appeared as a sphericalmorphology and they were about 150 nm in mean hydrodynamic diameter with negative charge. The fluorescent magnetic probe had a little toxic effect on hepG2 cells and increased the specificity liver cancer diagnosis by AFP antibody target imaging in model mouse of liver cancer. In brief, the AFP antibody conjugated fluorescent magnetic probe is a promising multi-functional tool with good biocompatibility and high sensitivity and specificity for clinical cancer diagnosis and therapy.上海pg电子娱乐游戏app 生物技术出具相关的产品设备:DSPE-PEG-MalDSPE-RBDSPE-PEI-DextranLyP-1-PEG-DSPEAngiopep-2 PEGDSPE-PEG-CSNRDARRC(二硬脂酰基磷脂酰无水乙醇胺-聚乙二醇-*靶向疗法蛋白酶)DSPE-PEG-BSA上文篇文章內容起源以及期刊杂志或论文参考文献,以免商标侵权请沟通人们去除!