名称模块型聚乙二醇化壳聚糖纳米级颗粒物的提纯和定性分析小说作家肖巨颖; 赵霞; 林园; 苏朝晖期刊论文网页链接：//openurl.ebsco.com/EPDB%3Agcd%3A14%3A17421374/detailv2?sid=ebsco%3Aplink%3Acrawler&id=ebsco%3Adoi%3A10.19894%2Fj.issn.1000-0518.240425&link_origin=none论文摘要：In the present study, Carboxyl and azide terminated polyethylene (N3-PEG-COOH) with different relative molecular mass of 500 and 1000 were grafted onto the chitosan (CS) backbones through amide reaction, followed by the preparation of chitosan-polyethylene glycol (CS-PEG) nanoparticles with controllable size and zeta potential via sodium tripolyphosphate (TPP) ionotropic gelation. Characterized by Fourier transform infrared spectrometer (FT-IR), nuclear magnetic resonance spectroscopy (NMR) and thermal gravimetric analyzer (TGA) confirmed the successful incorporation of PEG, and the structures of the nanoparticles were analyzed by transmission electron microscopy (TEM) and nanoparticle size and zeta potential analyzer. The results demonstrated that when m (CS) ∶m (TPP) is 3.33∶1, CS nanoparticles show excellent structural stability. Based on this, increasing the PEG grafting density further reduces the particle size and surface potential of CS-PEG nanoparticles. Moreover, the chemical reactivity of azide in CS-PEG nanoparticles was proved by the click reaction with alkyne-modified fluorescent molecule (5-FAM-alkyne), showing their potential as platform for target drug delivery, fluorescent probes and other biomedical applications.

在本深入阐述一下中，凭借酰胺发应将相对比较原子核产品质量为500和1000的羧基和叠氮封中端聚氯乙烯（N3-PEG-COOH）接枝到壳聚糖（CS）骨地上，然后呢凭借三聚磷酸钠（TPP）阴离子疑胶化制取图片尽寸和ζ电极电位差可以控制的壳聚糖-聚乙二醇（CS-PEG）nm离子。凭借傅里叶变幻红外光谱仪图仪（FT-IR）、核磁振动光谱仪图（NMR）和热重阐述一下仪（TGA）的阐述方法得知了PEG的取得成功掺加，并凭借手机散射手机高倍显微镜（TEM）和nm离子图片尽寸和ζ电极电位差阐述一下仪阐述一下了nm离子的空间结构。结杲说明，当m（CS）∶m（TPP）为3.33∶1时，CSnm微粒的表现出表现出色的结构设计不稳界定性。应用软件场景此，增强PEG接枝强度进一个步骤减小了CS-PEGnm科粒剂的孔径和从表面电位差。显然，能够与炔烃淡化的荧光原子核（5-FAM-炔烃）的点击事件影响，发现了叠氮化物在CS-PEGnm科粒剂中的药剂学影响性，屏幕上显示了他们作靶点性药物递送、荧光电极和一些生物技术医学专业应用软件的平台的提升空间。有关的高性价比：COOH-PEG-HZCOOH-PEG-SSPLA(2K)-PEG-COOHPDLLA(5K)-PEG-COOHCOOH-PEG-PLA(10K)PLGA(8K)-PEG-COOHNO2-Bn-PEG-COOHDA-PEG-COOHPLGA(40K)-PEG-COOHPLGA(15K)-PEG-COOHCOOH-PEG-NH2.HClPLGA(1K)-PEG-COOHCOOH-PEG-CH2CH2COOtBu以下信息信息源于种类期刊杂志或文章，如果侵犯商标权请联络我国删掉！