参考文献：聚乙二醇化壳聚糖-氟尿嘧啶偶合物的化学合成及身体保持理论研究写作者：段萍萍，关鹏程，朱亮文献资料链接转换： Objective: To synthesize PEGylated chitosan fluorouracil conjugate (5-FU-CS-mPEG) and investigate its in vitro release propertiesMethod: Carboxylated monomethoxypolyethylene glycol (mPEG COOH) was reacted with chitosan (CS) to prepare polyethylene glycol monomethyl ether modified chitosan (mPEGCS), which was then coupled with chloroacetic acid modified fluorouracil (FUA) in the presence of 1-ethyl - (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC · HCl)/N-hydroxysuccinimide (NHS) to form the target product 5-FU-CS-mPEG; Characterize the structure using UV, 1H-NMR, FT-IR; UV method for calculating prodrug loading; Using dynamic dialysis method to study prodrug release rateAs a result of structural confirmation, 5-FU-CS-mPEG was successfully synthesized; The degree of substitution of mPEG was calculated to be 12.31% by 1H-NMR; The drug loading capacity is 4.83%; The cumulative release of macromolecular prodrug at 120 hours is 57% Conclusion: 5-FU-CS-mPEG has a certain sustained release effect

主要目的炼制聚乙二醇化壳聚糖-氟尿嘧啶偶合物(5-FU-CS-mPEG),并观察其身体之外移除性.具体方法以羧基化单甲氧基聚乙二醇(mPEG-COOH)与壳聚糖(CS)响应制备聚乙二醇单甲醚热塑性树脂壳聚糖(mPEGCS),再与经氯乙酸体现的氟尿嘧啶(FUA)在1-乙基-(3-二甲基氨基丙基)碳酰二亚胺硫酸盐(EDC·HCl)/N-羟基蜜腊酰亚胺(NHS)介导下与CS偶联,转化指标代谢物5-FU-CS-mPEG;用UV,1H-NMR,FT-IR对形式实行定性分析;UV法统计前药载药量;采取最新透析法论述前药降低度.但是经构造确证,获得成功合出了5-FU-CS-mPEG;经1H-NMR求算mPEG的充当度为12.31%;载药量为4.83%;大脂溶性前药在120 h的积攒发出量为57%.论证 5-FU-CS-mPEG存在需要的控释的作用.各种相关介绍：NHS-PEG-COOHNHS-PEG-RGDOPSS-PEG-NHSPCL(5K)-PEG-NHSPh-PEG-NHSPLGA(20K)-PEG-NHSPLGA(5K)-PEG-NHSY-shape-PEG-NHS4-ArmPEG-(3Alkyne-1NHS)4-ArmPEG-(3Biotin-1NHS)8-ArmPEG-(2ARM-NHS,6ARM-Biotin)Biotin-PEG-NHSBiotin-PEG4-S-S-NHSmPEG-SS-NHSNHS-PEG-NHSPDLLA(5K)-PEG-NHS综上所述相关内容相关内容来源地四种刊物或参考文献，若有侵犯知识产权请去联系他们去除！