文献资料：DSPE-MPEG2000体现的七叶素纳米级框架脂质质粒的胃中外考核及*乙状结肠炎活性氧超链接：//www.tandfonline.com/doi/abs/10.1080/02652048.2023.2215345编辑：冯石，殷文雄，迈克尔·阿杜-弗林蓬，李潇潇，夏晓丽，孙伟刚，浩吉，埃尔穆拉特·托列尼亚佐夫，王启龙，夏草ORCIDps图标，江南地区于&徐熙明节选：主观的将七叶亭封装类型于DSPE-MPEG2000形式中，以提供其水溶解性和服食生态学利于度，并增进其对葡聚糖氢氧化钠钠（DSS）可能会导致的小鼠胃溃疡性小肠炎实体模型的*炎效用。方式 确立了七叶素内部外高效性液质色谱(HPLC)分享工艺；按照透明膜解聚法纪备七叶素nm结构设计脂质质粒(Esc-NLC)，用粒度分布分享仪测量Esc-NLC的粒度分布(PS)和电势(ZP)，用散发出电子厂高倍显微镜(TEM)洞察分析其形貌，用HPLC测量其载药量(DL)、包封率(EE)和药物制剂的体内施放度，并考虑药代能源学主要参数。除此之外，使用HE染色剂切开企业方面的问题学诊断和ELISA化学制剂盒检查测量血清中*死亡成分-α(TNF-α)、白癌细胞介素(IL)-1β(β)、IL-6的酸度，点评其*小肠炎帮助。

ObjectiveEncapsulation of esculetin into DSPE-MPEG2000 carrier was performed to improve its water solubility and oral bioavailability, as well as enhance its anti-inflammatory effect on a mouse model of ulcerative colitis that was induced with dextran sulphate sodium (DSS).MethodsWe determined the in-vitro and in-vivo high-performance liquid chromatographic (HPLC) analysis method of esculetin; Esculetin-loaded nanostructure lipid carrier (Esc-NLC) was prepared using a thin-film dispersion method, wherein a particle size analyser was used to measure the particle size (PS) and zeta potential (ZP) of the Esc-NLC, while a transmission electron microscope (TEM) was employed to observe its morphology. Also, HPLC was used to measure its drug loading (DL), encapsulation efficiency (EE) and the in-vitro release of the preparation, as well as investigate the pharmacokinetic parameters. In addition, its anti-colitis effect was evaluated via histopathological examination of HE-stained sections and detection of the concentrations of tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1 beta (β), and IL-6 in serum with ELISA kits.宝鸡pg电子娱乐游戏app 海洋生物可以提供相关联的产品：DSPE-PEG-Glycine triarginineDODMADSPE-PEG-TH（二硬脂酰基磷脂酰无水乙醇胺-聚乙二醇-PH为了响应性肿瘤细胞穿膜肽)DMPE-PEG-NH2m-PEG8-DSPEPentacosadiynoic acid-MPEGC18-PEGn-OHDSPE-PEG-c(RGDfK)-FITCiRGD-PEG-MAL之上小文章知识起源各项中文核心期刊或资料，此事商标侵权请连系让我们册除！