资料：DSPE-MPEG2000绘制的七叶素纳米技术节构脂质膜蛋白的身上外评测及*直肠炎亲水性环节：//www.tandfonline.com/doi/abs/10.1080/02652048.2023.2215345作著：冯石，殷文雄，迈克尔·阿杜-弗林蓬，李潇潇，夏晓丽，孙伟刚，浩吉，埃尔穆拉特·托列尼亚佐夫，王启龙，夏草ORCID苹果图标，江东于&徐熙明节选：主观性的将七叶亭封装类型于DSPE-MPEG2000质粒中，以从而提高其水无水磷酸氢和内服生物工程借助度，并增强学习其对葡聚糖磷酸钠（DSS）诱因的小鼠胃溃疡性乙状结肠炎仿真模型的*炎做用。方式方法制定了七叶素肚子里外更高效高效液相色谱(HPLC)定量进行分析办法；用于保护膜分散性法冶备七叶素nm格局脂质媒介(Esc-NLC)，用粒度分布定量进行测试仪测得法Esc-NLC的粒度(PS)和电极电位(ZP)，用散发出电子器材光学显微镜(TEM)了解其形貌，用HPLC测得法其载药量(DL)、包封率(EE)和药物的身体之外解放度，并考察调研药代和系统动力学结构基本参数。前者，顺利通过HE染色的切块策划 病检学查和ELISA化学药品盒检侧血清中*挫裂分子-α(TNF-α)、白血细胞介素(IL)-1β(β)、IL-6的氨水浓度，考核其*乙状结肠炎使用。

ObjectiveEncapsulation of esculetin into DSPE-MPEG2000 carrier was performed to improve its water solubility and oral bioavailability, as well as enhance its anti-inflammatory effect on a mouse model of ulcerative colitis that was induced with dextran sulphate sodium (DSS).MethodsWe determined the in-vitro and in-vivo high-performance liquid chromatographic (HPLC) analysis method of esculetin; Esculetin-loaded nanostructure lipid carrier (Esc-NLC) was prepared using a thin-film dispersion method, wherein a particle size analyser was used to measure the particle size (PS) and zeta potential (ZP) of the Esc-NLC, while a transmission electron microscope (TEM) was employed to observe its morphology. Also, HPLC was used to measure its drug loading (DL), encapsulation efficiency (EE) and the in-vitro release of the preparation, as well as investigate the pharmacokinetic parameters. In addition, its anti-colitis effect was evaluated via histopathological examination of HE-stained sections and detection of the concentrations of tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1 beta (β), and IL-6 in serum with ELISA kits.北京pg电子娱乐游戏app 生态学打造有关系物料：DSPE-PEG-Glycine triarginineDODMADSPE-PEG-TH（二硬脂酰基磷脂酰甲醇胺-聚乙二醇-PH死机性肿瘤细胞穿膜肽)DMPE-PEG-NH2m-PEG8-DSPEPentacosadiynoic acid-MPEGC18-PEGn-OHDSPE-PEG-c(RGDfK)-FITCiRGD-PEG-MAL大于篇文章知识源于四种论文期刊或期刊论文，要是有图片侵权请找话题当我们删了！