论文参考文献：PEG-Immunoliposome 我：Kazuo Maruyama文献资料联接： 引言：This review deals with the current status of newly developed pendant-type PEG-immunoliposomes (Type C), carrying monoclonal antibodies or their fragments (Fab') at the distal ends of the PEG chains. In terms of target binding of Type C, two different anatomical compartments are considered. They are mouse lung endothelium as a readily accessible site via the intravascular route and the implanted solid tumor as a much less accessible target site reached via extravasation. Small unilamellar liposomes (90–130 nm in diameter) were prepared from phosphatidycholine and cholesterol (2:1, m/m) containing 6 mol.% of DSPE-PEG-COOH or DPPE-PEG-Mal. For targeting to the vascular endothelial surface in the lung, 34A antibody, which is highly specific to mouse pulmonary endothelial cells, was conjugated to PEG-liposomes (34A-Type C). The degree of lung binding of 34A-Type C in BALB/c mouse was significantly higher than that of 34A-Type A, which is an ordinary type of immunoliposome (without PEG derivatives). For targeting to solid tumor tissue, 21B2 antibody (anti-human CEA) and its Fab' fragment were used. The targeting ability of Fab'-Type C was examined by using CEA-positive human gastric cancer strain MKN-45 cells inoculated into BALB/c nu/nu mice. Fab'-Type C showed low RES uptake and a long circulation time, and enhanced accumulation of the liposomes in the solid tumor was seen. The small Fab'-Type C predominantly passed through the leaky tumor endothelium by passive convective transport. These studies offer important insights into the potential of Type C liposomes for target-specific drug delivery.

下面研究了新开设发的悬垂型PEG免疫细胞脂质体（C型）的行业现状，该脂质体在PEG链的远端带上单克隆表面抗原或其片断（Fab’）。就C型的靶根据如何理解，了解了两大有所不同的解剖学区室。同旁内角是小鼠肺内皮，做一个能够淋巴管内路线极易停靠的连接，包括种植的物理瘤，做一个能够外渗停靠的不太极易停靠的任务连接。由有6mol%DSPE-PEG-COOH或DPPE-PEG-Mal的磷脂酰胆碱和胆固醇高（2:1，m/m）配制小单双层脂质体（内径90-130nm）。只为靶向疗法肺淋巴管内皮漆层，将对小鼠肺内皮细胞膜非常特异的34A抗原与PEG脂质体（34A C型）通过。在BALB/C小鼠中，34A C型的肺融合层次取得多于34A A型，后面就是种硬性的免疫抗体脂质体（可含PEG衍生产品物）。考虑到靶向药物实物瘤组织性，选用了21B2免疫抗体（抗人CEA）和其Fab’段落。Fab'-C型现示低RES摄取量和长嵌套循环日期，如果就能够听到脂质体在实物瘤中的积淀资料。小Fab’-C型注意使用闪避自然通风搬运走过流出的肉瘤内皮。此类科学研究为C型脂质体靶向口服药口服药递送的优势展示 了非常重要看法。相关联比较适合：Mal-PEG-SS Mal-PEG-SGMal-PEG-PCL(3K)PLGA(18K)-PEG-MalPLGA(12K)-PEG-MalFA-PEG-MalMAL-PEG-PLA(2K)Mal-PEG-SVAPCL(12K)-PEG-MalPLGA(50:50)(8K)-PEG-MalPLGA(5K)-PEG-MalMal-PEG-SCDBCO-PEG-MalAlKyne-PEG-MalMA-PEG-MalMal-PEG-COOH上述好的文章方面因素各期刊论文或专著，此事知识产权侵权请找话题让我们清空！