论文：Development of PLGA-PEG-COOH and Gelatin-Based Microparticles Dual Delivery System and E-Beam Sterilization Effects for Controlled Release of BMP-2 and IGF-1小编：Yan Bai, Seyedsina Moeinzadeh, Sungwoo Kim, Youngbum Park, Elaine Lui, Hua Tan, Weiling Zhao, Xiaobo Zhou, Yunzhi Peter Yang学术论文联结： 论文摘要：A poly(lactic-co-glycolic acid)-poly(ethylene glycol)-carboxyl (PLGA-PEG-COOH) and gelatin-based microparticles (MPs) dual delivery system for release of bone morphogenetic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) is developed. The delivery system is characterized based on its morphology, loading capacity, encapsulation efficiency, and release kinetics. The effects of electron beam (EB) sterilization on BMP-2 and IGF-1-loaded MPs and their biological effects are examined. The synergistic effect of a controlled dual release of BMP-2 and IGF-1 on osteogenesis of human mesenchymal stem cells (MSCs) is evaluated. Encapsulation efficiency of growth factors into gelatin and PLGA-PEG-COOH MPs is in the range of 64.78% to 76.11%. E-beam sterilized growth factor delivery systems are effective in significantly promoting osteogenesis of MSCs, although E-beam sterilization decreases the bioactivity of growth factors in MPs by ≈22%. BMP-2 release behavior from gelatin MPs/PEG hydrogel shows a faster release (52.7%) than that of IGF-1 from the PLGA-PEG-COOH MPs/PEG hydrogel (27.3%). The results demonstrate that the gelatin and PLGA-PEG-COOH MPs-based delivery system can realize temporal release of therapeutic biomolecules by incorporating different growth factors into distinct microparticles. EB sterilization is an accessible method for sterilizing growth factors-loaded carriers, which can pave the way for implementing growth factor delivery in clinical applications.

建设一堆种适用施放骨状态出现血清-2（BMP-2）和胰岛素样成长因素-1（IGF-1）的聚乳酸-聚乙二醇-羧基（PLGA-PEG-COOH）和明胶基水分子（MP）双递送系统化。递送模式的优点就在其价值形式、额定装载能力素质、包封错误率和移除牵引运动学。探索了电子设备束（EB）杀菌对额定装载BMP-2和IGF-1的MP的应响举例说明海洋分子生物学反应。评价了BMP-2和IGF-1的受控两个移除对之间充质干组织（MSCs）成骨的分工协作功效。萌发发育分子在明胶和PLGA-PEG-COOH MP中的包封学习效率在64.78%至76.11%直接。网上束消毒的萌发发育分子递送系統能有效果相关系数催进MSCs的成骨，我以为网上束消毒会使MP中萌发发育分子的菌物生物降底约22%。明胶MPs/PEG水凝露的BMP-2保持形为比PLGA-PEG-COOH MPs/PEG凝露的IGF-1保持形为（27.3%）很快（52.7%）。结论说明，研究背景明胶和PLGA-PEG-COOH MP的递送模式是可以使用将不一的植物的生长因素参入不一的粒子来达成医治性生物技术原子的目前保持。关联引荐：IA-PEG-COOHAC-PEG-COOHAlKyne-PEG-COOHCOOH-PEG-EPOCOOH-PEG-MACOOH-PEG-N3CHO-PEG-COOHBiotin-PEG-COOHFmoc-NH-PEG-COOHBoc-NH-PEG-COOHMal-PEG-COOHSH-PEG-COOH综上所述主要内容主要内容来自种类学术期刊或专著，假如有版权侵权请关系让我们删除图片！