医学文献：整合食用的药物传输：使用 31P 和 2H NMR 光谱图研究方法 DLin-KC2-DMA/二硬脂酰磷脂酰丝氨酸外链：//summit.sfu.ca/item/15257做者：林赛·T·雷德里克逊张迪周克进李桑明刘帅肖恩·A·迪利亚德卢卡斯·法比亚克苏曼塔·查特吉林市玉轩丹尼尔·J·西格瓦特*节选：脂质納米科粒 (LNP) 用到借助内吞效果和接着随后的内体增加将 siRNA 递准时到达肝组织。犹豫 99% 的 LNP 是借助内吞效果被组织汲取的，于是只剩下 1% 的 siRNA 实打实被增加到组织质中。为了能让不断提高 LNP 与内体膜组合和其破环的很好性，应用 2H 和 31P NMR 光谱仪法定量分析了由 1:1 摩尔比的阴硝酸根铁离子脂质 1,2-二硬脂酰(d70)-sn-甘油-3-[磷酸-L-丝氨酸] (DSPS-d70) 和阳硝酸根铁离子脂质 DLin-KC2-DMA 构造的沙盘仿真模型机制的动物数学性能指标。效果认为，该沙盘仿真模型机制从双重相向倒五角形相 (HII) 的相变受温度因素、pH 值和盐氧化还原电位的影向。兑换了序叁数区域划分图，阐释了DSPS-d70在双重膜和HII相中酰基链健身运动的的情况。哪些效果利于为计算出来模拟仿真、*终升级优化的LNP设计打造参照。

Lipid nanoparticles (LNPs) are used to deliver siRNA to hepatocytes via endocytosis and subsequent endosomal release. With 99% of the LNPs taken up by the cell via endocytosis, only 1% of the siRNA is actually released into the cell cytosol. To improve the effectiveness of LNPs association with and disruption of endosomal membranes, the biophysical properties of a model system composed of 1:1 molar ratio of anionic lipid 1,2-distearoyl(d70)-sn-glycero-3-[phospho-L-serine] (DSPS-d70) and the cationic lipid DLin-KC2-DMA are characterized by 2H and 31P NMR spectroscopy. The bilayer to inverted hexagonal (HII) phase transition of the model system was shown to be influenced by temperature, pH and salt concentration. The order parameter profiles are obtained, revealing the extent of acyl chain movement of DSPS-d70 in bilayer and HII phases. The results help provide insights into computational simulation and eventually optimized LNPs design.西安市pg电子娱乐游戏app 怪物保证有关于企业产品：DSPE-NHSDSTAP (18:0)DSPE-PEG-SHCy3-DPPEDSPE-PEG-HADPPE-PEG-N3Cy7-DOPE及以上文章信息内容信息内容主要来源当下学术期刊或论文，如果有侵犯著作权请搞好关系我们的移除！