论文参考文献：Polymeric Micelles Modified by Folate-PEG-Lipid for Targeted Drug Delivery to Cancer Cells In Vitro小说作品： Hayama, Akihiro; Yamamoto, Tatsuhiro; Yokoyama, Masayuki; Kawano, Kumi; Hattori, Yoshiyuki; Maitani, Yoshie资料图片链接：//www.ingentaconnect.com/contentone/asp/jnn/2008/00000008/00000006/art00040英文论文：A novel technique was developed for the formation of ligand-targeted polymeric micelles that can be applicable to various ligands. For tumor-specific drug delivery, camptothecin (CPT)-loaded polymeric micelles were modified by folate to produce a folate-receptor-targeted drug carrier. Folate-linked PEG5000-distearoylphosphatidylethanolamine (folate-PEG5000-DSPE) was added when preparations of drug-loaded polymeric micelles, resulting in folate ligands exposed to the surface. Folate-modified CPT-loaded polymeric micelles (F-micelle) were evaluated by measuring cellular uptake using a flow cytometer, fluorescence microscopy, and confocal laser scanning microscopy, and by cytotoxicity measurement. The results revealed that F-micelle showed higher cellular uptake in KB cells over-expressing folate receptor (FR) and higher cytotoxicity compared with non-folate modified CPT-loaded polymeric micelles (plain micelles) in KB cells, but not in FR-negative HepG2 cells. This result indicated that polymeric micelles were successfully modified by the folate-linked lipid.

搭建半个种新高技术，应用建立可适应用很多配体的配体靶向治疗疗法缩聚物胶束。相对 肺部肿瘤炎症因子朋友制剂递送，额定负载喜树碱（CPT）的缩聚物胶束被DHA突显，生成DHA感觉靶向治疗疗法制剂平台。当光催化原理负债抗癫痫药物的配位聚苯胺胶束时，参加DHA接入的PEG5000二硬脂酰磷脂酰甲醇胺（Folate-PEG5000-DSPE），致使DHA配体暴晒在从表面。可以通过适用流式的组织组织上皮细胞仪、荧光光学显微镜和共专注离子束扫描仪扫描光学显微镜估测组织组织上皮细胞摄食、组织组织上皮细胞毒副作用估测来评估报告格式DHA淡化的CPT负债配位聚苯胺胶束（F-胶束）。报告是因为，与KB组织人体血上皮细胞中没有孕妇叶酸片装饰的CPT阻抗汇聚物胶束（常见胶束）相对比，F-胶束在过抒发孕妇叶酸片感觉（FR）的KB组织人体血上皮细胞中展现出更快一些的组织人体血上皮细胞摄食率和更快一些的毒副作用，但在FR弱阳的HepG2组织人体血上皮细胞中则他怕。哪一结果显示说明，DHA接入的脂质出色地绘制了汇聚物胶束。有关介绍：DSPE-PEG-AlkyneDSPE-PEG-RhodamineDSPE-RhodamineDSPE-PEG-SHDSPE-PEG-SPDPDSPE-SPDPDSPE-PEG-TFPDSPE-PEG13-TFPDSPE-PEG-Vinylsulfone以下文章标题信息源于各论文期刊或论文资料，见谅侵犯著作权请结合我们的清空！