资料：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy我：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie文献资料外链：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801文献综述：Our previous study has revealed that TFPI-2 is expressed at a low level in NPC cells and tissues [16]. As proof of concept we use FA as targeting molecules, which conjugated to amino-terminated polyethylene glycol (NH2-PEG-COOH) and polyethylenimine (PEI) to perform cationic polymers (FA-PEG-PEI) via amidation. Aldehyde sodium alginate modified Fe3O4 magnetic particles coated cisplatin (SPION-CDDP) was constructed with the above cationic polymer to obtain composite carriers (FA-PEG-PEI@SPION-CDDP), which then adsorbed TFPI-2 pDNA via electrostatic interaction to obtain the FA-targeted, CDDP, and TFPI-2-coated nanocomposites (FA-PEG-PEI@SPION-CDDP-TFPI-2). In vitro assays indicated that the novel compounds possessed excellent load-carrying capacity and drug stability and showed negligible cytotoxicity and enhanced targetability to FR positive (FR+) NPC HNE-1 cells.

的研究体现了，TFPI-2在鼻咽癌内部和进行中的表答关卡较低。是 凡路认可，让我们食用FA是 靶向疗法原子核，它与氨基封店铺推广聚乙二醇（NH2-PEG-COOH）和聚氯乙烯亚胺（PEI）共轭，在酰胺化组成阳化合物配位聚苯胺（FA-PEG-PEI）。用综上所述阳正离子合成树脂物建设了醛-海带酸钠改良的Fe3O4永久磁铁离子包裹顺铂（SPION-CDDP），以拥有结合形式(FA-PEG-PEI@SPION-CDDP)，并且在静电反应上下级帮助吸咐TFPI-2 pDNA，拥有FA靶点疗法、CDDP和TFPI-2涂覆的奈米结合物料(FA-PEG-PEI@SPION-CDDP-TFPI-2).身体校正显示，新氧化物还具有良好的承受本事和制剂动态平衡性，对FR阳性反应（FR+）NPC HNE-1血生殖细胞的血生殖细胞毒副作用是可以忽略掉不计较，靶点疗法性开展。一些比较适合：OH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OHPLL-PEG-OHPLGA(10K)-PEG-OHSilane-PEG-OH以内句子方式渠道多种论文期刊或期刊论文，如不商标侵权请电话联系咱们删除图片！