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mPEG-PCL-PLL纳米胶束的合成与基因负载性能研究
发布时间:2025-07-24     作者:kx   分享到:
文献资料:可生物体可降解阳阴正离子三嵌段共聚物mPEG-PCL-PLL的自动合成简答用以siRNA递送联结://www.sciencedirect.com/science/article/abs/pii/S016836591100681X写作者:若谷 奇 1 2,美丽效果 湖 5号,乐山市 燕 1 2,陈学思 1,黄玉斌 1,夏 滨井 1节选:依据对mPEG-PCL端部羟基来去叠氮化,再对叠氮基来去氢化,提炼了端氨基甲氧基聚乙二醇-b-聚己内酯(mPEG-PCL-NH 2 )。通过吸引ε-CBz(L-赖氨酸)-N-羧酸酐的开环聚合反应,实现阳铝正化合物三嵌段共聚物甲氧基聚乙二醇-b-聚己内酯-b-聚L-赖氨酸(mPEG-PCL-PLL)。该共聚物可在底层的水中也可以直接自拆装成具备有疏水关键和阳铝正化合物冠层的納米级胶束。因,什么和什么也可以进每一步与阴铝正化合物siRNA组合,还有机会用做什么是基因递送。

mPEG-PCL-PLL

Amino-terminated methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL-NH2) was synthesized by azidizing the end OH group of mPEG-PCL and by subsequent hydrogenation of the azido group. It was used to initiate ring-opening polymerization of ε-CBz (L-lysine)-N-carboxyanhydride to obtain cationic triblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(L-lysine) (mPEG-PCL-PLL). The copolymer could self-assemble directly in water into nanoscale micelles with a hydrophobic core and a cationic corona. Therefore, they can further complex with anionic siRNA for possible application in gene delivery.西安市pg电子娱乐游戏app 生物制品给出各种相关物品:PLL-OPSSTrt-PLLFITC-PLLPGA-AldehydePGA-N3PGA-SHPGA-BiotinPGA-NH2PGA-ALKPGA-OPSSTrt-PGA综上所述一篇文章资源种类几大类杂志期刊或论文参考文献,如果发现侵犯著作权请连接人们误删!