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聚合物-多肽/蛋白质共聚物
发布时间:2020-10-16     作者:wyf   分享到:

外表上的聚合反应物-多肽/蛋白酶质共聚物

本诗论述了表皮共价接枝的多肽/血清质的合成视频技巧基本电学、化学物质研究方法步骤技木。换取种外表面接枝的主要是技巧涉及聚合反应物链的“嫁连接到(grafting to)”或“稼接于(grafting from)”方式方法,在这之后再支承肽/蛋清质。一些可能将不太正规的自动合成物试管移植到外表面上。

Abstract:

Background: Polymer-peptide/protein conjugates immobilized on surface have gained considerable attention, mostly due to their broad scope of applications in biomedical fields. To optimize their properties, the combined knowledge of polymer chemistry and biochemistry has to be applied.

Method: The main methods to obtain such surfaces involve “grafting to” or “grafting from” of polymeric linkers with subsequent attachment of a peptide/protein. Alternatively, a “ready-made” conjugate may be grafted to the surface.

Result: The structure of the polymer linker significantly influences the properties of the active surface, and a variety of physicochemical methods and tools have been successfully applied to study the structure-property relationship of these surfaces.

Conclusion: This review outlines the applied synthetic strategies leading to covalently attached bioconjugates on the surface and the characterization techniques used to study those materials. The relevance of different linear polymeric linkers and their influence on the properties of the obtained materials is discussed.

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