期刊论文：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy期刊论文的链接：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205作著：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su内容提要：Preparation and characterization of pH-sensitive DSPE-PEG-Imide-MTX assembling micellar nanoparticles loaded with CUR (MTX-Imine-M-CUR)Because of inherent amphiphilicity, DSPE-PEG-Imine-MTX and DSPE-MPEG could spontaneously self-assemble into micellar nanoparticles (MTX-Imine-M) composed of an inner hydrophobic DSPE core and an outside hydrophilic PEG shell with a self-targeting prodrug corona when exposed to the aqueous solution. The CUR drug could be encapsulated within the hydrophobic core of MTX-Imine-M (MTX-Imine-M-CUR) through hydrophobic interactions. The MTX-Imine-M-CUR nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). In addition, the M-CUR (nanocarriers were self-assembled by DSPE-MPEG) and the MTX-Amide-M-CUR (nanocarriers were self-assembled by DSPE-PEG-Amide-MTX and DSPE-MPEG) were fabricated as comparative formulations (Figure 1B). The TEM observation of all drug formulations (Figure 2A–C) confirmed the monodispersed spherical nanoparticles. With DLS measurement, all nanoparticles showed a mean hydrodynamic particle size of 20–30 nm with negative surface charge (Figure 2A–C), which might facilitate preventing potential aggregations via electrostatic repulsion and decrease the nonspecific interaction between nanoparticles and plasma protein/red blood cells. 

基于其确定性的两亲性，当曝光于水稀硫酸中时，DSPE-PEG-Imine-MTX和DSPE-MPEG就可以组织地自組裝成胶束nm级塑料颗粒（MTX-Imine-M），该nm级塑料颗粒由的内部疏水性聚氨酯聚氨酯DSPE核心内容和外观亲水性聚氨酯聚氨酯PEG金属外壳组成了，享有自靶向治疗前药冠。CUR食用的药物可能顺利完成疏水主动用途包封在MTX-Imine-M（MTX-Imine-M-CUR）的疏水管理的本质内。顺利完成动态化光散射（DLS）和散射光学显微镜（TEM）对MTX-Imine-M-CUR纳米级阿尔法粒子开始了定性分析。

此外，M-CUR（纳米载体由DSPE-MPEG自组装）和MTX-酰胺-MCUR（纳米粒子由DSPE-PEG-酰胺-MTX和DSPE-MPEG自行组装）被制备为比较制剂。所有药物制剂的TEM观察证实了单分散的球形纳米颗粒。通过DLS测量，所有纳米粒子的平均流体动力学粒径为20-30nm，表面带负电荷，这可能有助于通过静电排斥防止潜在的聚集，并减少纳米粒子与血浆蛋白/红细胞之间的非特异性相互作用。

涉及到的比较适合产品设备：DSPE-PEG-SCDSPE-PEG-SCMDSPE-PEG-SGDSPE-PEG-SHDSPE-PEG-SilaneDSPE-PEG-SP2-AADSPE-PEG-SSDSPE-PEG-TCODSPE-PEG-TetrazineDSPE-PEG-TMS这文章资源资源的来源各大学术期刊或资料，告之侵权行为请连接企业删除图片！