医学文献：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy专著联接：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205我：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su结语：Preparation and characterization of pH-sensitive DSPE-PEG-Imide-MTX assembling micellar nanoparticles loaded with CUR (MTX-Imine-M-CUR)Because of inherent amphiphilicity, DSPE-PEG-Imine-MTX and DSPE-MPEG could spontaneously self-assemble into micellar nanoparticles (MTX-Imine-M) composed of an inner hydrophobic DSPE core and an outside hydrophilic PEG shell with a self-targeting prodrug corona when exposed to the aqueous solution. The CUR drug could be encapsulated within the hydrophobic core of MTX-Imine-M (MTX-Imine-M-CUR) through hydrophobic interactions. The MTX-Imine-M-CUR nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). In addition, the M-CUR (nanocarriers were self-assembled by DSPE-MPEG) and the MTX-Amide-M-CUR (nanocarriers were self-assembled by DSPE-PEG-Amide-MTX and DSPE-MPEG) were fabricated as comparative formulations (Figure 1B). The TEM observation of all drug formulations (Figure 2A–C) confirmed the monodispersed spherical nanoparticles. With DLS measurement, all nanoparticles showed a mean hydrodynamic particle size of 20–30 nm with negative surface charge (Figure 2A–C), which might facilitate preventing potential aggregations via electrostatic repulsion and decrease the nonspecific interaction between nanoparticles and plasma protein/red blood cells. 

伴随其之前的两亲性，当体现于水氢氧化钠溶液中时，DSPE-PEG-Imine-MTX和DSPE-MPEG还可以自行地自拼装成胶束纳米级级粒子束束（MTX-Imine-M），该纳米级级粒子束束由里面的疏水溶性DSPE层面和内部亲水溶性PEG的外壳构成的，兼备自靶点前药冠。CUR中成药也可以经由疏水相互间效用包封在MTX-Imine-M（MTX-Imine-M-CUR）的疏水中心内。经由最新光散射（DLS）和散射电子厂透射电镜（TEM）对MTX-Imine-M-CUR纳米技术塑料颗粒做了研究方法。

此外，M-CUR（纳米载体由DSPE-MPEG自组装）和MTX-酰胺-MCUR（纳米粒子由DSPE-PEG-酰胺-MTX和DSPE-MPEG自行组装）被制备为比较制剂。所有药物制剂的TEM观察证实了单分散的球形纳米颗粒。通过DLS测量，所有纳米粒子的平均流体动力学粒径为20-30nm，表面带负电荷，这可能有助于通过静电排斥防止潜在的聚集，并减少纳米粒子与血浆蛋白/红细胞之间的非特异性相互作用。

涉及到推建产品的：DSPE-PEG-SCDSPE-PEG-SCMDSPE-PEG-SGDSPE-PEG-SHDSPE-PEG-SilaneDSPE-PEG-SP2-AADSPE-PEG-SSDSPE-PEG-TCODSPE-PEG-TetrazineDSPE-PEG-TMS之内本文玩法渠道各种类型期刊论文或学术论文，假如有版权侵权请连接.我删掉！