参考文献：Liver-Targeted Combination Therapy Basing on Glycyrrhizic Acid-Modified DSPE-PEG-PEI Nanoparticles for Co-delivery of Doxorubicin and Bcl-2 siRNA小说作品：Guixiang Tian&#x;Guixiang Tian1†Ruiyan Pan&#x;Ruiyan Pan2†Bo Zhang&#x;Bo Zhang2†Meihua QuMeihua Qu2Bo LianBo Lian1Hong JiangHong Jiang1Zhiqin Gao*Zhiqin Gao1*Jingliang Wu*Jingliang Wu1*论文链接搜索：

Synthesis of DSPE-PEG-PEI ConjugatesBi-functional DSPE-PEG-NHS was used to conjugate with PEI via the primary amine reactive NHS ester moiety at weakly basic pH, thus avoiding the conjugation and crosslinking of the maleimide groups to the amine functions of PEI, which occurs at higher pH (pH > 8). The structure of DSPE-PEG-NHS, PEI and resulting DSPE-PEG-PEI copolymer were verified by 1H NMR. The peaks of PEG (3.6 ppm, -CH2O-), DSPE (1.0–1.5 ppm, -CH2-) and PEI (2.5–3.0 ppm, CH2-N) were confirmed. The1H-NMR spectrum of DSPE-PEG-PEI in D2O exhibited characteristic peaks at 2.5–3.0 ppm (peaks of PEI), 3.6 ppm (peaks of PEG) and 1.0–1.5 ppm (peaks of DSPE), indicating that PEI was successfully introduced to the DSPE-PEG-NHS molecular.

DSPE-PEG-PEI共轭物的获得双官能DSPE-PEG-NHS适用于在弱碱性食物pH下进行伯胺想法性NHS酯的部分与PEI偶联，最后以免 了马来酰亚胺基团与PEI胺官能团的偶联和化学交联，这在较高pH值（pH>8）印发生。能够1H NMR证实了DSPE-PEG-NHS、PEI和个人所得DSPE-PEG-PEI共聚物的机构。PEG（3.6ppm，-CH2O-）、DSPE（1.0-1.5ppm，-CH2-）和PEI（2.5-3.0ppm，CH2-N）的峰已被明确。D2O中DSPE-PEG-PEI的1H NMR光谱分析在2.5-3.0 ppm（PEI峰）、3.6 ppm（PEG峰）和1.0-1.5 ppm（DSPE峰）处显示信息出本质特征峰，反映PEI不复功形成DSPE-PEG-NHS分子结构。涉及到的高性价比：DSPE-PEG-MethyltetrazineDSPE-PEG-MTXDSPE-PEG-nano goldDSPE-PEG-NBDSPE-PEG-NBDDSPE-PEG-NPCDSPE-PEG-NTA-NIDSPE-PEG-PCLDSPE-PEG-PDPDSPE-PEG-PEIDSPE-PEG-PLA上面稿件內容源于常见杂志期刊或资料，如果侵犯著作权请联系起来我删去！