专著：两亲性聚乙二醇接枝共聚物的离散库：合出、組裝和菌物特异性跳转：//pubs.acs.org/doi/abs/10.1021/jacs.2c07859小说家：陈俊峰奥恩·里兹维约瑟夫·P·帕特森克雷格·J·霍克*节选：聚乙二醇 (PEG) 是种更重要且范围广采用生物学和制药业论述方向的缩聚物，其用处是*大装量地极大减少非炎症因子朋友配合，并且有效改善*/三维成像剂的新陈代谢系统系统循环系统。只不过，市售 PEG 印刷品有着多增溶性，这的阻碍了对其链长依赖性优点的简略论述，并将会在类药软件中不断增强*体反应迟钝。文章，他们汇报一个多种适用且可扩大的具体方法，采用化学镶嵌有着支链非非线形网络框架的离散 PEG 之类物库。以下脂质-PEG 发展物学有着单增溶主链，其侧链分为离散量的乙二醇單元（3 或 4 个）和*的可功用化链端。适合目光的是，与市售多增溶非线形网络体制（比如 DMG-PEG2000）相对比，此种支链非非线形网络框架已被素材书就能达到目标更高效的nm粒子装设，并且减少* PEG *体自动识别率。利用达到目标多接枝共聚物库的可扩大镶嵌，可不可以的理解其总体的自装设优点，并素材书其与 PEG 單元数、链端概念和主链总长短直观各种相关。以下导致说明白离散大原子与常用增溶素材相对比的资源优势。AbstractPoly(ethylene glycol) (PEG) is an important and widely used polymer in biological and pharmaceutical applications for minimizing nonspecific binding while improving blood circulation for therapeutic/imaging agents. However, commercial PEG samples are polydisperse, which hampers detailed studies on chain length-dependent properties and potentially increases antibody responses in pharmaceutical applications. Here, we report a practical and scalable method to prepare libraries of discrete PEG analogues with a branched, nonlinear structure. These lipid-PEG derivatives have a monodisperse backbone with side chains containing a discrete number of ethylene glycol units (3 or 4) and unique functionalizable chain ends. Significantly, the branched, nonlinear structure is shown to allow for efficient nanoparticle assembly while reducing anti-PEG antibody recognition when compared to commercial polydisperse linear systems, such as DMG-PEG2000. By enabling the scalable synthesis of a broad library of graft copolymers, fundamental self-assembly properties can be understood and shown to directly correlate with the total number of PEG units, nature of the chain ends, and overall backbone length. These results illustrate the advantages of discrete macromolecules when compared to traditional disperse materials.

绵阳pg电子娱乐游戏app 生物体打造有关系新产品：DSPE-PEG-Angiopep-2 (二硬脂酰基磷脂酰酒精胺-聚乙二醇-聚合素靶向治疗环肽)DSPE-PEG-CLSDSPE-PEG2K-R8DSPE-PEG-TRITCDSPE-PEG-BiotinPeptides PEG PCLDSPE-PEG-HZDPPE-PEG-RGD之内篇文章的内容来原多种刊物或医学文献，告之侵权行为请搞好关系我们的删除图片！