文献资料：两亲性聚乙二醇接枝共聚物的离散库：镶嵌、制造和生物学可溶性网页链接：//pubs.acs.org/doi/abs/10.1021/jacs.2c07859写作者：陈俊峰奥恩·里兹维约瑟夫·P·帕特森克雷格·J·霍克*节选：聚乙二醇 (PEG) 都是种决定性且非常广泛用到生物学和生物制药层面的缔合物，其意义是*大幅度地也可以减少非特喜欢的人搭配，时候缓和*/激光散斑剂的动脉血循坏。以至于，市售 PEG 样本有多乳状液性，这的阻碍了对其链长根据性优点的相信调查，并能在口服药应用软件中加强*体表现。文章，公司意见书新一种实惠且可扩充的方式 ，用到制取有支链非非非线形组成的离散 PEG 有些相似物库。许多脂质-PEG 衍生物物学有单乳状液主链，其侧链其中包含离散人数的乙二醇象限（3 或 4 个）和*的可职能化链端。有必要注意事项的是，与市售多乳状液非非线形采集体系（举列 DMG-PEG2000）较之，各种支链非非非线形组成已被证实能完成高效率的的nm颗粒状主装，时候减轻* PEG *体鉴别率。经过完成很多接枝共聚物库的可扩充生成，也可以认为其基本上的自主装优点，并证实其与 PEG 象限比例、链端类型和主链总的长度进行相关的。许多成果说明白离散大原子与经典乳状液食材较之的优势。AbstractPoly(ethylene glycol) (PEG) is an important and widely used polymer in biological and pharmaceutical applications for minimizing nonspecific binding while improving blood circulation for therapeutic/imaging agents. However, commercial PEG samples are polydisperse, which hampers detailed studies on chain length-dependent properties and potentially increases antibody responses in pharmaceutical applications. Here, we report a practical and scalable method to prepare libraries of discrete PEG analogues with a branched, nonlinear structure. These lipid-PEG derivatives have a monodisperse backbone with side chains containing a discrete number of ethylene glycol units (3 or 4) and unique functionalizable chain ends. Significantly, the branched, nonlinear structure is shown to allow for efficient nanoparticle assembly while reducing anti-PEG antibody recognition when compared to commercial polydisperse linear systems, such as DMG-PEG2000. By enabling the scalable synthesis of a broad library of graft copolymers, fundamental self-assembly properties can be understood and shown to directly correlate with the total number of PEG units, nature of the chain ends, and overall backbone length. These results illustrate the advantages of discrete macromolecules when compared to traditional disperse materials.

北京pg电子娱乐游戏app 生物制品带来了相应护肤品：DSPE-PEG-Angiopep-2 (二硬脂酰基磷脂酰工业乙醇胺-聚乙二醇-聚合素靶向治疗环肽)DSPE-PEG-CLSDSPE-PEG2K-R8DSPE-PEG-TRITCDSPE-PEG-BiotinPeptides PEG PCLDSPE-PEG-HZDPPE-PEG-RGD之上小文章信息来自多种期刊论文或资料，如不侵权案请搞好关系我们都删除文件！