论文：磷脂绘制的PEI基納米的载体用做内siRNA*多药抗药性*连接：//www.nature.com/articles/gt201497创作者：埃塞克斯郡中北部G纳瓦罗P·萨巴钱达尼，思维导图膜M Trivedi，S Movassaghian＆副总经理裁托尔奇林节选：线下店瘤中P-糖球球蛋白过表达出介导的多药抗药效(MDR)是四种放手术验证失败的主要是要素。本理论钻研评诂了磷脂装饰的分低子量聚丁二烯亚胺(DOPE-PEI)納米质粒适用动脉输送管*P-糖球球蛋白siRNA至*的目的，不可能计划是自我调节乳线癌的MDR。要，当小编理论钻研了DOPE-PEI納米质粒的生物体匀称还有PEG涂覆在皮下组织乳线*建模 中的意义。填充后四1天，PEG化质粒在减弱的覆盖性和拒载边际效应，在线下店瘤中积聚了8%的填充服用量(ID)，原因PEG介导的无限循环时长廷长，在血清中积聚了22%的ID。二，当小编选定了DOPE-PEI/siRNA介导的P-gp调低聯合阿霉素(Dox)放手术在MCF-7/MDR异种移殖瘤中的有效时间和防护性。每一周填充siRNA納米药物和Dox，快速将近5周，使*对本没用服用量的Dox生产辨别力状态性，并使*体积大小与对比组对比降低了多倍。这一对Dox有效时间的改进归因于DOPE-PEI药物介导的切掉*中有效的字段特喜欢的人P-gp调低。

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here we evaluated phospholipid-modified, low-molecular-weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to tumors with the final goal of modulating MDR in breast cancer. First, we studied the biodistribution of DOPE-PEI nanocarriers and the effect of PEG coating in a subcutaneous breast tumor model. Four hours postinjection, PEGylated carriers showed an 8% injected dose (ID) accumulation in solid tumor via the enhanced permeability and retention effect and 22% ID in serum due to a prolonged, PEG-mediated circulation. Second, we established the therapeutic efficacy and safety of DOPE-PEI/siRNA-mediated P-gp downregulation in combination with doxorubicin (Dox) chemotherapy in MCF-7/MDR xenografts. Weekly injection of siRNA nanopreparations and Dox for up to 5 weeks sensitized the tumors to otherwise non-effective doses of Dox and decreased the tumor volume by threefold vs controls. This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations.昆明pg电子娱乐游戏app 生物工程带来了有关的车辆：DSPE-PyreneDSPE-ThiolDSPE-PEG-GE11(二硬脂酰基磷脂酰工业乙醇胺-聚乙二醇-*细胞膜仁衣发育指数公式EGFR靶向治疗肽)DSPE-PEG-HisDSPE-PEG-cRGD(二硬脂酰基磷脂酰乙酸乙酯胺-聚乙二醇-优势互补素靶点环肽)ALC-0315DOPE-PEG-MalDSPE-PEG-M2pepDSPE-PEG-cisplatinDSPEGPC3靶向药物肽-PEG-DSPE以内句子內容来原以及论文期刊或文章，假如侵犯商标权请沟通让我们删掉！