论文参考文献：磷脂修饰语的PEI基纳米级的载体用作体內siRNA*多药抗药性*环节：//www.nature.com/articles/gt201497写作者：埃塞克斯郡北部G纳瓦罗P·萨巴钱达尼，思维导图膜M Trivedi，S Movassaghian＆副总经理裁托尔奇林节选：实体化的瘤中P-糖蛋清过展示介导的多药抗药力(MDR)是多种类放手术超时的一般环境因素。本钻研评价了磷脂装饰的分太低子量聚氯乙烯亚胺(DOPE-PEI)納米质粒媒体应用在静脉打推送*P-糖蛋清siRNA至*的结果，然后最终目标是调整乳房增生癌的MDR。首要，你们钻研了DOPE-PEI納米质粒媒体的菌物划分同时PEG涂膜在肉里乳房增生*绘图中的滞后效应。打后四小时英文，PEG化质粒媒体可以通过激发的固化性和留在牙齿上滞后效应，在实体化的瘤中沉淀了8%的打摄入量(ID)，在PEG介导的循环往复精力变长，在血清中沉淀了22%的ID。前者，你们判别了DOPE-PEI/siRNA介导的P-gp上涨连合阿霉素(Dox)放手术在MCF-7/MDR异种移值瘤中的功效和人身安全系数。每星期打siRNA納米溶液剂和Dox，保持过去了5周，使*对原先无用摄入量的Dox发生强烈性，并使*质量与剖析组想必减小了五倍。本身对Dox功效的提高归因于DOPE-PEI溶液剂介导的切除术*中同质性的回文序列特喜欢的人P-gp上涨。

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here we evaluated phospholipid-modified, low-molecular-weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to tumors with the final goal of modulating MDR in breast cancer. First, we studied the biodistribution of DOPE-PEI nanocarriers and the effect of PEG coating in a subcutaneous breast tumor model. Four hours postinjection, PEGylated carriers showed an 8% injected dose (ID) accumulation in solid tumor via the enhanced permeability and retention effect and 22% ID in serum due to a prolonged, PEG-mediated circulation. Second, we established the therapeutic efficacy and safety of DOPE-PEI/siRNA-mediated P-gp downregulation in combination with doxorubicin (Dox) chemotherapy in MCF-7/MDR xenografts. Weekly injection of siRNA nanopreparations and Dox for up to 5 weeks sensitized the tumors to otherwise non-effective doses of Dox and decreased the tumor volume by threefold vs controls. This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations.杭州pg电子娱乐游戏app 生物工程提高相应的商品：DSPE-PyreneDSPE-ThiolDSPE-PEG-GE11(二硬脂酰基磷脂酰乙酸乙酯胺-聚乙二醇-*组织细胞表皮层滋生分子EGFR靶向药物肽)DSPE-PEG-HisDSPE-PEG-cRGD(二硬脂酰基磷脂酰工业乙醇胺-聚乙二醇-整和素靶向治疗环肽)ALC-0315DOPE-PEG-MalDSPE-PEG-M2pepDSPE-PEG-cisplatinDSPEGPC3靶点肽-PEG-DSPE以上的篇文章信息内容主要来源各种学术期刊或论文参考文献，如遇侵权行为请保持联系咱们误删！