文献资料：Biodegradable and biocompatible multi-arm star amphiphilic block copolymer as a carrier for hydrophobic drug delivery小编：S Aryal，M Prabaharan，S Pilla，S Gong论文微信链接：//xueshu.baidu.com/usercenter/paper/show?paperid=d61fdc2f0b9e8919635b549acaef41be&site=xueshu_se结语：Multi-arm star amphiphilic block copolymers (SABCs) with approximately 32 arms were synthesized and characterized for drug delivery applications. A hyperbranched polyester, boltorn~_ H40 (H40), was used as the macroinitiator for the ring-opening polymerization of s-caprolactone (ε-CL). The result_ing multi-arm H40-poly(ε-caprolactone) (H40-PCL-OH) was further reacted with carboxyl terminated methoxy poly(ethylene glycol) (MPEG-COOH) to form H40-PCL-b-MPEG copolymers. The resulting SABCs were characterized by ~1H NMR spectroscopy and gel permeation chromatography (GPC). The critical aggregation concentration (CAC) of H40-PCL-b-MPEG was 3.8 mg/L as determined by fluorescence spec_trophotometry. Below the CAC, stable unimolecular micelles were formed with an average diameter of 18 nm as measured by TEM. Above the CAC, unimolecular micelles exhibited agglomeration with an aver_age diameter of 98 nm. The hydrodynamic diameter of these agglomerates was found to be 122 nm, as measured by dynamic light scattering (DLS). The drug loading efficacy of the H40-PCL-b-MPEG micelles was 26 wt%. Drug release study showed an initial burst followed by a sustained release of the entrapped hydrophobic model drug, 5-fluorouracil, over a period of 9-140 h. These results indicate that the H40- PCL-b-MPEG micelles have great potential as hydrophobic drug delivery carriers.

合成图片了兼有约3多个臂的多臂星形两亲嵌段共聚物（SABC），并对其实施了表现，以运用于药物治疗气流输送运用。选用超支化聚酯树脂bolten_H40（H40）充当s-己内酯（ε-CL）开环聚合反应的大原子引起剂。使偶然偶然所得的多臂H40-聚（ε-己内酯）（H40-PCL-OH）进一大步与羧基封端甲氧基聚（乙二醇）（MPEG-COOH）生理反应以型成H40-PCL-b-MPEG共聚物。偶然偶然所得的SABC凭借1H NMR光谱分析和抑菌凝胶渗透性色谱（GPC）实行研究方法。使用荧光分光光度法法测定，H40-PCL-b-MPEG的临介聚在一起盐浓度（CAC）为3.8 mg / L。在CAC右上方，建成平衡的单氧分子胶束，使用TEM在线测量其大概直劲为18nm。在CAC上边，单大分子胶束的表现出相聚，大概内径为98 nm。能够 动态图片光散射（DLS）測量，察觉到他们附聚物的文丘里管磁学内径为122nm。 H40-PCL-b-MPEG胶束的载药性比率为26权重％。肿瘤中成药施放探讨显示，刚开始的发展是紧接着在9-140小内不断施放所包着的疏水模板肿瘤中成药5-氟尿嘧啶。某些然而表述，H40-PCL-b-MPEG胶束极具用于疏水口服药物递送质粒载体的竞争力。有关于网友推荐：mPEG-COOHmPEG-CH2CH2COOHAlkene-PEG-COOHI-PEG-COOHNB-PEG-COOHc(RGDyK)-PEG-COOHPLGA(17K)-PEG-COOHPhosphoric acid-PEG-COOHCOOH-PEG-N+Me3PCL(2K)-PEG-COOHCOOH-PEG-SS-PEG-COOHC18-PEG-COOHDA-PEG-CH2COOH以上的一篇文章游戏内容源以及杂志或文献综述，如无侵犯知识产权请电话联系人们删除文件！