论文资料：In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy著者；Ruoyan Wei,a   Wensong Xi,b   Haifang Wang,b   Jinliang Liu,a   Torsten Mayr,c   Liyi Shia  and  Lining Sun文献资料链接转换： 结语：A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility. The final UCNPs@Au-DOX nanocomposites offer efficient treatment effects in vitro under irradiation with an 808 nm laser due to the synergistic effect of chemotherapy and photothermal therapy. In addition, the UCNPs@Au-DOX nanocomposites show excellent intracellular locating ability via upconversion luminescence (UCL) imaging with Er3+ ions and magnetic resonance imaging (MRI) with Gd3+ ions, indicating that they have potential as a visual tracking agent in cancer treatment. Therefore, the presented bioimaging-guided multifunctional synergistic therapy nanocomposites are promising tools for imaging-guided cancer therapy.

确立来并镶嵌没事种多种系统表*症奈米结合素材，将pH回应性SH-PEG-DOX前药连入到原位种子发芽在上还原成奈米粒子（UCNP）接触面的金奈米奈米线上。在SH-PEG-DOX前药的型式中，采取腙键在*症体血细胞膜的体血细胞膜内弱酸性微的环境中做好后来的pH回应性口服药物宣泄。种创新发展的主装工艺非常简单一个温和，用于于刷出UCNP和金的奈米结合素材，现示出优等的光可靠性和生态学相融性。冠军赛UCNPs@Au-DOX基于化疗药和光热开展的分工协作效应，奈米结合素材在808nm皮秒激光直射下到身体外出示了有效的的开展效率。再者UCNPs@Au-DOX奈米结合素材顺利通过Er3+化合物的上变为放光（UCL）影像和Gd3+化合物的磁共震影像（MRI）现示出优等的体血细胞膜内确定力，取决于它们的在*症开展中兼具自身的机器人视觉关注剂。由此，所确立来的生态学影像导识多种系统表分工协作开展奈米结合素材是影像导识*症开展的有就业前景的工具软件。重要性介绍：ACA-PEG-SHSH-PEG-OHAC-PEG-SHAlKyne-PEG-SHMA-PEG-SHN3-PEG-SHSH-PEG-BiotinFmoc-NH-PEG-SH不低于文章方式方式来源于以及期刊杂志或文章，见谅版权侵权请沟通公司册除！