论文参考文献：In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy小说作者；Ruoyan Wei,a   Wensong Xi,b   Haifang Wang,b   Jinliang Liu,a   Torsten Mayr,c   Liyi Shia  and  Lining Sun资料联结： 论文摘要：A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility. The final UCNPs@Au-DOX nanocomposites offer efficient treatment effects in vitro under irradiation with an 808 nm laser due to the synergistic effect of chemotherapy and photothermal therapy. In addition, the UCNPs@Au-DOX nanocomposites show excellent intracellular locating ability via upconversion luminescence (UCL) imaging with Er3+ ions and magnetic resonance imaging (MRI) with Gd3+ ions, indicating that they have potential as a visual tracking agent in cancer treatment. Therefore, the presented bioimaging-guided multifunctional synergistic therapy nanocomposites are promising tools for imaging-guided cancer therapy.

提拱并合并新一种智能型模块*症nm级组合村料，将pH反映性SH-PEG-DOX前药衔接到原位成长在上转变成nm级科粒（UCNP）表面能的金nm级氯化钠晶体上。在SH-PEG-DOX前药的结构的中，利用率腙键在*症肿瘤癌细胞膜的肿瘤癌细胞膜内强酸微大环境中实施紧接着的pH反映性改善药物施放。此种转型升级的組裝做法简约无刺激，用于于拥有UCNP和金的nm级组合村料，显视出非常好的光安稳性和海洋生物学混溶性。公开赛UCNPs@Au-DOX鉴于肿瘤化疗和光热改善的联动反应，nm级组合村料在808nm激光行业的照射传到身体提拱了合理有效的改善机器人视觉效果。不仅而且UCNPs@Au-DOXnm级组合村料用Er3+正正离子的上转变发光字广告（UCL）三维显像和Gd3+正正离子的磁共震三维显像（MRI）显视出非常好的肿瘤癌细胞膜内标记水平，显示同旁内角在*症改善中具备着风险的机器人视觉跟踪目标剂。如此，所提拱的海洋生物学三维显像引领智能型模块联动改善nm级组合村料是三维显像引领*症改善的有发展前景的设备。相应的引荐：ACA-PEG-SHSH-PEG-OHAC-PEG-SHAlKyne-PEG-SHMA-PEG-SHN3-PEG-SHSH-PEG-BiotinFmoc-NH-PEG-SH以下稿件信息来自常见杂志期刊或文章，如遇知识产权侵权请联系起来我们的刪除！