专著：Palladium cubes with Pt shell deposition for localized surface plasmon resonance enhanced photodynamic and photothermal therapy of hypoxic tumors†我们：Wenxiang Gu ab, Zhiyuan Hua b, Zheng Li ab, Zhiheng Cai a, Wandong Wang a, Kaijin Guo b, Feng Yuan b, Fenglei Gao ORCID logo*a and Hongliang Chen论文资料链接代码：//pubs.rsc.org/en/content/articlehtml/2022/bm/d1bm01406d英文论文：Multifunctional phototherapy nanoagents for imaging-guided synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) are highly desirable in the field of solid tumor therapy. Nevertheless, the tumor microenvironment (TME) inherently associated with hypoxia significantly hampers the photodynamic effect of these multifunctional nanoagents. Herein, Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyethylene glycol (FITC-PEG-SH) (denoted as Pd@Pt-PEG). The deposition of a Pt shell on Pd nanocubes not only enhances the photothermal performance, exhibiting excellent hyperthermia outcomes and impressive photothermal (PT) imaging quality, but also leads to the formation of singlet oxygen (1O2) induced by plasmonic excitation. In the meantime, the catalytic activity of the Pt layer is enhanced by electronic coupling and the plasmonic effect, which induces the decomposition of endogenous overexpressed hydrogen peroxide (H2O2) in tumors to generate O2 for conquering TME and augmenting 1O2 generation for efficacious tumor cell apoptosis. The modification of FITC-PEG-SH improves the biocompatibility and provides outstanding fluorescence (FL) imaging properties. Upon NIR laser irradiation, Pd@Pt-PEG allows in situ O2 generation and dual-mode imaging-guided synergistic PTT/PDT that effectively kills hypoxic tumor cells, which makes it a promising nanotherapeutic agent for enhanced tumor therapy.

用做影像帮助的协同管理光热控制方式（PTT）和光原因控制方式（PDT）的多性能光疗微米剂在实际瘤控制行业领域受喜爱。不过，与缺痒僵板想关的肉瘤微的环境（TME）重要拘束了等多性能微米类药的光原因调节作用。此前，化学合成了涂有超轻薄Pt壳的Pd奈米立方米米体，并举步骤与荧光素箭头和巯基官能化的聚乙二醇（FITC-PEG-SH）（说道为Pd@Pt-PEG).Pt壳在Pd奈米立方米米体上的沉积状这不仅不断增强了光热性食物能，表面出出色的热药效果和最让人城市印象受益匪浅的光热（Pt）影像安全性能，而还促使等亚铁离子体调动促进的单线态氧（1O2）的养成。互相，Pt层的促使催化活性经过电子设备藕合和等铝离子体效用受到强化，这引导了恶性肉瘤中内源性过把你想表达出来的过空气氧化氢（H2O2）的被分解转换成，导致了O2以对战TME，并提升1O2的导致了以满足有效果的恶性肉瘤人体细胞凋亡。FITC-PEG-SH的增韧加强了怪物混溶性，并提供数据了表现出色的荧光（FL）成相特点。在NIR激光机器直接照射下，Pd@Pt-PEG不能原位O2自动生成和双模成相加以引导的推进PTT/PDT，有效果干掉缺养良性癌症内部，这使其已成为不断增强良性癌症疗法的有趋势的微米疗法剂。涉及推薦：FITC-PEG-DTPAFITC-PEG-EstrogenFITC-PEG-LAFITC-PEG-MTXFITC-PEG-NiacinFITC-PEG-OPSSFITC-PEG-PCL(2K)FITC-PEG-PCL(5K)FITC-PEG-ProgestroneFITC-PEG-SCFITC-PEG-SilaneFITC-PEG-TretinoinICG-PEG-AlkyneICG-PEG-Biotin以内本文主要内容源各大论文期刊或论文参考文献，此事版权侵权请去联系他们卸载！