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PCL-PEG-Mal共聚物的合成与功能化
发布时间:2025-07-22     作者:kx   分享到:
论文资料:马来酰亚胺官能化聚(ε-己内酯)-嵌段-聚乙二醇(PCL-PEG-MAL):结合、奈米颗粒剂造成和硫醇共轭跳转://onlinelibrary.wiley.com/doi/abs/10.1002/macp.200900025我们:吉胜祥, 朱正熙, 托马斯·R·霍伊, 克里斯托弗·W·马科斯科节选:合成视频了兼具窄多消减性的羧酸封鍴的聚(ε-己内酯)(PCL-COOH),并将其与聚(乙二醇)(HO-PEG-OH)偶联,获取PCL-PEG-OH共聚物。接下来将PCL-PEG-OH中的羟基图片转换为马来酰亚胺基团,获取所含70–90%马来酰亚胺官能团的马来酰亚胺封鍴的PCL-PEG-MAL。根据撞击力混合式制作了界面兼具马来酰亚胺官能团的奈米粒状。根据静态光散射核查孔径和孔径占比。还證明了展现谷胱甘肽与模式化马来酰亚胺和俩种MAL官能团奈米粒状的整合。实用Ellman化学药品在测量了粒状界面可及马来酰亚胺的量,范围之内为≈51–67%。

PCL-PEG-Mal

AbstractCarboxylic acid terminated poly(ε-caprolactone)s (PCL-COOHs) with narrow polydispersity were synthesized and coupled with poly(ethylene glycol) (HO–PEG–OH) to afford PCL-PEG–OH copolymers. The hydroxyl groups in the PCL-PEG–OHs were then converted to maleimide groups to afford maleimide terminated PCL-PEG-MALs that contained 70–90% maleimide functionality. Nanoparticles with maleimide functionality on their surfaces were prepared by impingement mixing. Particle sizes and size distributions were determined by dynamic light scattering. Conjugation of reduced glutathione with model maleimides and two MAL-functional nanoparticles was also demonstrated. The amount of accessible maleimide on the particle surface was measured using Ellman's reagent to range between ≈51–67%.广州pg电子娱乐游戏app 动物提供数据涉及到产品设备:PCL-PEG-FolatePCL-PEG-BiotinPCL-GlucosePCL-g-PEIPCL-HeparinPCL-PEG-HeparinPCL-GalactosePCL-PEG-Galactose以上的软文信息从何而来各样杂志或专著,深表歉意侵犯知识产权请搞好关系自己删掉!