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SH-PEG-COOH介导的金纳米棒多功能表面修饰及细胞穿透肽偶联
发布时间:2025-07-23     作者:zyl   分享到:
论文:Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals小编:Qiu, Xiaozhong; Wang, Yaling; Cui, Yanyan; Sun, Zhipeng; Liu, Ru; Huang, Wenhua; Zhao, Feng; Zu, Yan; Yuan, Hui; Chang, Xueling; Gao, and Xueyun学术论文地址://www.ingentaconnect.com/contentone/asp/jnn/2012/00000012/00000009/art00004小结:Surface functionalized gold nanorods (GNRs) with three optical signals and the ability to track and observe live cells was investigated. The Cetyltrimethyl Ammonium Bromide (CTAB) was used as the shape-directing agent to develop GNRs with uniform size and aspect ratio. The as-synthesized GNRs can strongly enhance the Raman signal of the attached MGITC on the GNRs. Polyethylene glycol (SH-PEG-COOH) and SH-PEG-FITC were attached with GNRs through ligand exchange with CTAB. They can stabilize the GNRs, reduce the cytotoxicity and provide fluorescence signal. A cell-penetrating peptide was covalently conjugated with SH-PEG-COOH to assist the GNRs to enter living cell. After cultured with the MCF-7 cells, the surfaced functionalized Au nanorods can enter the MCF-7 cells and be tracking with enhanced MGITC Raman signal, FITC fluorescence, and Rayleigh scatter signal.

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学习了有四种光无线数据信息的漆层功能模块化金纳米技术棒(GNR)与跟进和观察动物活血细胞的力量。操作16烷基三级甲等医院基溴化铵(CTAB)为线条支撑剂,制作出厚度和横纵比匀的GNR。合出的GNR可热烈不断增强GNR上衔接的MGITC的拉曼无线数据信息。聚乙二醇(SH-PEG-COOH)和SH-PEG-FITC顺利通过与CTAB的配体互相交换与GNR实现连接。植物的根就能够稳定性GNR,大幅度降低组织渗透性并提供数据荧光数字表现。组织吸收肽与SH-PEG-COOH共价融合,以好处GNR进活组织。与MCF-7组织同时训练后,外面官能化的Au納米棒就能够进MCF-7组织,用以增强学习的MGITC拉曼数字表现、FITC荧光和瑞利散射数字表现实现跟进。涉及到推薦:Palmitic acid-PEG-MalPalmitic acid-PEG-NH2Palmitic acid-PEG-SCRB-PEG-DSPESTA-PEG-CHOSTA-PEG-COOHSTA-PEG-FASTA-PEG-FITCSTA-PEG-MalSTA-PEG-NBDSTA-PEG-NH2超过句子游戏内容由来各项刊物或论文,比如侵犯商标权请认识各位删掉!