论文参考文献：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy作家：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie医学文献超链接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801小结：considered the cross-coupling reaction between the above cationic carriers and nonionic water-soluble polymers PEG to increase the solubility and decrease aggregation of the composites. Besides that, the combination between CDDP and aldehyde sodium alginate modified SPION is more capable of adsorbing PEG modified PEI via electrostatic interaction due to the improved biocompatibility, water-solubility, and longer circulation time in blood. Meanwhile, the targeting FA-PEG-PEI was prepared by amidation reaction between the carboxyl groups of FA and amino groups of NH2-PEG-OH. Finally, FA-PEG-PEI@SPION-CDDP-TFPI-2 nanocomplex was performed by linking FA-PEG-PEI with SPION-CDDP and CDDP according to appropriate proportion. In vitro assay demonstrated the superiority of the nanocomplex in specific targetability for FR+ tumors.

注意了以上的阳铝铁离子媒介和非铝铁离子水可溶缩聚物PEG两者彼此的交叉重合偶联不起的功效，以延长包覆相关材料的分解度并抑制集结。显然，基于生物工程相可溶性、水可溶和外周血反复的时期更长，CDDP和醛-海苔酸钠体现的SPION两者彼此的搭配组合更能凭借电磁干扰互相的功效降解PEG体现的PEI。同时，利用FA的羧基与NH2-PEG-OH的氨基两者的酰胺化影响配制了靶向药物FA-PEG-PEI。最后的，FA-PEG-PEI@SPION-CDDP-TFPI-2利用将FA-PEG-PEI与SPION-CDDP和CDDP按相当的比例连到，完成納米复合材料物的配制。体内检验表述，纳米级黏结物在FR+良性肿瘤的活性聊天靶向治疗性上有着领先性。有关于推荐英文：Trt-PEG-OHBn2-PEG-OHBr-CH2CO-NH-PEG-OHOH-PEG-RGDOH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OH上文优秀文章玩法来自各大期刊杂志或医学文献，如不图片侵权请电话联系让我们移除！