论文资料：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy原作者：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie专著超链接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801提要：considered the cross-coupling reaction between the above cationic carriers and nonionic water-soluble polymers PEG to increase the solubility and decrease aggregation of the composites. Besides that, the combination between CDDP and aldehyde sodium alginate modified SPION is more capable of adsorbing PEG modified PEI via electrostatic interaction due to the improved biocompatibility, water-solubility, and longer circulation time in blood. Meanwhile, the targeting FA-PEG-PEI was prepared by amidation reaction between the carboxyl groups of FA and amino groups of NH2-PEG-OH. Finally, FA-PEG-PEI@SPION-CDDP-TFPI-2 nanocomplex was performed by linking FA-PEG-PEI with SPION-CDDP and CDDP according to appropriate proportion. In vitro assay demonstrated the superiority of the nanocomplex in specific targetability for FR+ tumors.

选择了以上阳铁铝离子各种载体和非铁铝离子水阴离子型缔合物PEG当中的交叉的情况偶联体现，以升高挽回文件的溶解能力度并少聚合。凡此种种，是由于生物工程相可溶、水阴离子型和鲜血嵌套循环時间更长，CDDP和醛-绿豆酸钠掩盖的SPION当中的结合更能能够 静电能上下级目的溶解PEG掩盖的PEI。此外，确认FA的羧基与NH2-PEG-OH的氨基相互之间的酰胺化表现提纯了靶向疗法FA-PEG-PEI。后面，FA-PEG-PEI@SPION-CDDP-TFPI-2确认将FA-PEG-PEI与SPION-CDDP和CDDP按有效百分比相连接，实施納米包覆物的提纯。身体外耐压试验反映，nm符合物在FR+良性肿瘤的特情人靶向药物性方向有着优渥性。有关的建议：Trt-PEG-OHBn2-PEG-OHBr-CH2CO-NH-PEG-OHOH-PEG-RGDOH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OH上述论文资源源头各种各样期刊论文或论文资料，如无侵犯知识产权请连续我们的全部删除！