文章：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy小编：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie文献资料友链：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801小结：1H NMR was determined to confirm the synthesis of FA-PEG-PEI (the spectrum and relevant chemical structural formula were shown in Figure 1). The characteristic peaks from 2.0 to 3.0 ppm (k, j) were attributed to -CH2CH2NH- group of PEI, the peaks at 3.66 ppm (h) were referred to -CH2CH2O- group of PEG, and the peaks from 6.5 to 9.0 ppm (a, b, c) were related to the H protons of benzene ring in FA [25]. The data suggested a successful combination of FA-PEG-PEI.The possible functional groups responsible for the synthesis of FA-PEG-PEI were further confirmed by FT-IR spectroscopy. Meanwhile, the FT-IR spectra of FA, NH2-PEG-OH, and NH2-PEG-COOH were also examined. The terminal hydroxyl groups of NH2-PEG-OH were of carboxylation and then combined with the amino groups of PEI via amidation reaction. As shown in Figure 2, the FT-IR spectra of terminal hydroxyl groups of (b) NH2-PEG-OH showed the presence of stretching vibration peak of -OH at 3440 cm−1, which shifted to a new stretching vibration peak of -C=O at 1629 cm−1 in (c) NH2-PEG-COOH after carboxylation. The FT-IR spectra of (d) FA-PEG-PEI displayed a broad peak at 3350–3250 cm−1, which refers to -NH2 and -NH- groups of PEI. The peaks at 1606–1460 cm−1 correspond to the benzene ring of FA. In addition, the peak at 1110 cm−1 is attributed to the symmetrical stretching vibration of -C-O-C- group in PEG, which declares the conjugation of FA-PEG-PEI.

测得1H NMR以验证FA-PEG-PEI的聚合。表现最高值在2.0到3.0彼此 ppm（k，j）归因于PEI的-CH2CH2NH-基团，最高值在3.66 ppm（h）是以PEG的-CH2CH2O-基团，峰在6.5至9.0彼此 ppm（a，b，c）与FA中苯环的H质子有观。数剧取决于，FA-PEG-PEI的组合式是出色的。FT-IR光谱分析分析进一大步表明了或许责任人FA-PEG-PEI组成的官能团。也，还研究方案了FA、NH2-PEG-OH和NH2-PEG-COOH的傅里叶调换红外光谱分析分析。NH2-PEG-OH的尾部羟基被羧化，那么经由酰胺化症状与PEI的氨基结合在一起。如图甲下图2下图，（b）NH2-PEG-OH尾部羟基的FT-IR光谱仪图屏幕上显示信息，在3440处普遍存在-OH的缩动震动幅度峰 cm-1，在1629处电信到新的拉伸运动震动幅度峰-C=O 羧化后，在（c）NH2-PEG-COOH里添加入cm-1。（d）FA-PEG-PEI的FT-IR光谱仪图在3350-3250处屏幕上显示信息没事个宽峰 cm-1表示法PEI的-NH2和-NH-基团。1606年至1460年的基线 cm-1各自于FA的苯环。不仅而且，1110处的峰 cm-1归因于PEG中-C-O-C-基团的不对称缩动震动幅度，这声明了FA-PEG-PEI的共轭。一些安利：HZ-PEG-OHPhthalimide-PEG-OHPLL-PEG-OHPLGA(10K)-PEG-OHSilane-PEG-OHOH-PEG-PAOH-PEG-SSOH-PEG-SGLA-PEG-OH上文短文介绍來源几大类杂志或论文，以免侵权案请认识企业删了！