专著：Targeting efficiency of PEG-immunoliposome-conjugated antibodies at PEG terminals写作者：Kazuo Maruyama a, Tomoko Takizawa a, Nobuya Takahashi a, Toshiaki Tagawa b, Kazuhiro Nagaike b, Motoharu Iwatsuru论文参考文献环节：//www.sciencedirect.com/science/article/abs/pii/S0169409X96004632

摘要：

We have developed a new type of PEG-immunoliposome carrying monoclonal antibodies or their fragments (F(ab′)2, Fab′) at the distal ends of the PEG chains (Type C). Distearoylphosphatidylethanolamine derivatives of PEG with car☐yl group (DSPE-PEG-COOH) or dipalmitoyl phosphatidylethanolamine derivatives of PEG with maleimidyl group (DPPE-PEG-Mal) at the PEG terminal were newly synthesized. Small unilamellar liposomes (90–130 nm in diameter) were prepared from distearoyl phosphatidylcholine and cholesterol (2:1, m/m) containing 6 mol% of DSPE-PEG-COOH or DPPE-PEG-Mal. To target to the vascular endothelial lung surface as a model accessible site, 34A antibody, which is highly specific to mouse pulmonary endothelial cells, was conjugated to PEG-liposome (34A-Type C). The degree of lung binding of 34A-Type C in BALB/c mice was significantly higher than that of the 34A-Type A which is an ordinary type immunoliposome (without PEG derivatives). To target to the solid tumor tissue as a model of the less accessible site, 21B2 antibody which is anti-human CEA and its Fab′ fragment were used. 

规划设计没事种新款的PEG免疫力脂质体，在PEG链的远端攜帶单克隆表面抗原或其电影片段（F（ab′）2，Fab′）（C型）。聚乙二醇二硬脂酰磷脂酰工业乙酸乙酯胺诞生物☐新合成视频了PEG端部帶有马来酰亚胺基的烷基（DSPE-PEG-COOH）或二棕榈酰磷脂酰工业乙酸乙酯胺诞生物（DPPE-PEG-Mal）。由含带6mol%DSPE-PEG-COOH或DPPE-PEG-Mal的二硬脂酰磷脂酰胆碱和低密度胆固醇（2:1，m/m）光催化原理了小一层脂质体（内直径90-130nm）。为了让靶向治疗心血管内皮肺表面层成为模型工具可及位点，将对小鼠肺内皮上皮细胞高速特女性朋友的34A抗体阳性与PEG脂质体（34A C型）相结合。BALB/C小鼠中34A C型的肺结合起来水平严重超出常规型免疫系统脂质体（含有PEG研究物）34A A型。要为靶向治疗实体的瘤组织结构当作不宜相当位置的类别，适用了抗人CEA的21B2抗体阳性下列不属于Fab′场面描写。想关介绍：mPEG-di-Glutamic AcidmPEG-FAmPEG-PEI(25K)mPEG-SBAmPEG-PCL(3K)mPEG-SS-C30mPEG-PCL(10K)mPEG-PCL(12K)mPEG-AlkenemPEG-DFmPEG-DBCOmPEG-DAmPEG-DansylmPEG-Ts 上玩法玩法來源各个论文期刊或文献资料，如不侵犯肖像权请建立联系他们卸载！