期刊论文：Targeting efficiency of PEG-immunoliposome-conjugated antibodies at PEG terminals创作者：Kazuo Maruyama a, Tomoko Takizawa a, Nobuya Takahashi a, Toshiaki Tagawa b, Kazuhiro Nagaike b, Motoharu Iwatsuru期刊论文微信链接：//www.sciencedirect.com/science/article/abs/pii/S0169409X96004632

摘要：

We have developed a new type of PEG-immunoliposome carrying monoclonal antibodies or their fragments (F(ab′)2, Fab′) at the distal ends of the PEG chains (Type C). Distearoylphosphatidylethanolamine derivatives of PEG with car☐yl group (DSPE-PEG-COOH) or dipalmitoyl phosphatidylethanolamine derivatives of PEG with maleimidyl group (DPPE-PEG-Mal) at the PEG terminal were newly synthesized. Small unilamellar liposomes (90–130 nm in diameter) were prepared from distearoyl phosphatidylcholine and cholesterol (2:1, m/m) containing 6 mol% of DSPE-PEG-COOH or DPPE-PEG-Mal. To target to the vascular endothelial lung surface as a model accessible site, 34A antibody, which is highly specific to mouse pulmonary endothelial cells, was conjugated to PEG-liposome (34A-Type C). The degree of lung binding of 34A-Type C in BALB/c mice was significantly higher than that of the 34A-Type A which is an ordinary type immunoliposome (without PEG derivatives). To target to the solid tumor tissue as a model of the less accessible site, 21B2 antibody which is anti-human CEA and its Fab′ fragment were used. 

开发设计新一种最新科技的PEG免疫检测脂质体，在PEG链的远端过飞机安检单克隆表面抗原或其片断（F（ab′）2，Fab′）（C型）。聚乙二醇二硬脂酰磷脂酰无水甲醇胺繁衍物☐新获得了PEG端部帶有马来酰亚胺基的烷基（DSPE-PEG-COOH）或二棕榈酰磷脂酰无水甲醇胺繁衍物（DPPE-PEG-Mal）。由有效6mol%DSPE-PEG-COOH或DPPE-PEG-Mal的二硬脂酰磷脂酰胆碱和胆固（2:1，m/m）光催化原理了小一层脂质体（半径90-130nm）。只为靶向疗法心血管内皮肺外壁做为仿真模型可及位点，将对小鼠肺内皮神经细胞层面特异形的34A免疫抗体与PEG脂质体（34A C型）紧密联系。BALB/C小鼠中34A C型的肺根据的情况看不出超出通常型天然免疫脂质体（富含PEG衍生产品物）34A A型。是为了靶向治疗实体型瘤组建为不可以将近脏器的沙盘模型，适用了抗人CEA的21B2免疫抗体十分Fab′细节描写。涉及推介：mPEG-di-Glutamic AcidmPEG-FAmPEG-PEI(25K)mPEG-SBAmPEG-PCL(3K)mPEG-SS-C30mPEG-PCL(10K)mPEG-PCL(12K)mPEG-AlkenemPEG-DFmPEG-DBCOmPEG-DAmPEG-DansylmPEG-Ts 上原创文章相关内容特征当下期刊论文或参考文献，此事侵权商标请认识企业全部删除！